International Journal of Pharma and Bio Sciences
 
 
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RESEARCH ARTICLE
Int J Pharm Bio Sci Volume 7, Issue 3, 2016 (July-Sept), Pages:191-204
ANALYSIS OF BIOACTIVE CHEMICAL COMPOUNDS OF ASPERGILLUS FUMIGATUS AND EVALUATION OF ANTIFUNGAL ACTIVITY USING TWENTY SEVEN MEDICINAL PLANTS
MOHAMMAD J. AL-JASSANI, GHAIDAA JIHADI MOHAMMED, IMAD HADI HAMEED
DOI:
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Abstract:

The objectives of this study were analysis of the secondary metabolite products from Aspergillus fumigatus and evaluation antibacterial activity. Fifteen bioactive compounds were identified in the methanolic extract of Aspergillus fumigatus. The identification of bioactive chemical compounds is based on the peak area, retention time molecular weight and molecular formula. GC-MS analysis ofAspergillus fumigatus revealed the existence of the 9-Hexadecenoic acid ,2,4-Dimethyl-5-methylthiopent-4-en-2-ol , E-11-Hexadecenoic acid , ethyl ester , D-Glucose , 6-O-α-D-galactopyranosyl- , α-D-Glucopyranoside , O-α-D-glucopyranosyl-(1.fwdarw.3)-β- , 6-Acetyl –β-d-mannose , 4H-Pyran-4-one,2,3-dihydro-3,5- dihydroxy-6-methyl- , 5-Hydroxymethylfurfural , β-D-Glucopyranoside, methyl , Tetraacetyl-d-xylonic nitrile , n-Hexadecanoic acid , 9-Octadecenoic acid , (2-phenyl-1,3-dioxolan-4-yl)methyl ester , Octadecanoic acid ,9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol,(3β,5Z,7E)- and Pyrimidin-2-ol,4-(3,4- dimethoxyphenyl)-6-phenyl. Gramineae poaceae was very highly antifungal activity (8.32±0.09) mm while
Streptococcus faecalis has a maximum zone formation (6.92±0.24) mm against Aspergillus fumigatus. 

Keywords: Aspergillus fumigatus, Antibacterial, Antifungal, GC/MS, Secondary metabolites
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