International Journal of Pharma and Bio Sciences
 
 
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ORIGNAL RESEARCH ARTICLE
Int J Pharm Bio Sci Volume 7 Issue 1, 2016 (January- March), Pages:45-55
ANTIMICROBIAL ACTIVITIES AND THE FIRST ISOLATION OF 4-NITROBENZOIC ACID TETRAHYDROFURAN-2-YL-METHYLESTER AND 4-HYDROXY-5-METHYLFURAN-3-ONE FROM TERRESTRIAL STREPTOMYCES SP.
SAYED A. AHMED, MAHMOUD AL-REFAI, ALZAHRAA OSAMA AND EMADELDIN M. KAMEL
DOI:
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Abstract:

In our investigation of the crude extracts from the terrestrial derived Streptomycete isolate sp. Wo 990, two compounds namely, 4-nitrobenzoic acid tetrahydrofuran-2-yl-methylester (1) and 4-hydroxy-5- methylfuran-3-one (5) were obtained for the first time from microorganisms. In addition, 2- phenylacetamide, 5-methyl-1H-pyrimidine-2,4-dione, 2-amino-3-phenyl-propionic acid and 2-(6-aminopurin-9-yl)-5-methyl-sulfanylmethyl-tetrahydrofuran-4-diol were isolated. The structures of the new compounds 1 and 5 were elucidated on the basis of spectroscopic analysis (1D and 2D), mass spectra and comparison with the literature data.

Keywords: Terrestrial streptomycetes, Nitrobenzoic acid derivative, Furanone, Natural products.
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