The following literature review is an available data about dental plaque biofilm which are complex communities of colonizing and acid producing bacteria.Dental biofilm consist of higher organism growing in population and undergoes maturation forming complex microbial community growing on enamel surface resulting in Oral mouth diseases. The slimy extracellular matrix produced by biofilm bacteria encloses the microbial community and protects it from harsh environmental attack. For cariogenisity of plaque many environmental factors are responsible. The change in Phisio-chemical properties of biofilm resulting in oral health issues. Streptococcus mutans bacteria was achieved higher in percentage of total positive cultures from plaque sample as compare to other streptoccoi group bacteria.Spread of Antibiotic resistence is probably the most common manifestation of the natural Genetic transformation in oral bacteria. Efficency of different antibiotic agents on isolated pathogenic strains from dental plaque.