International Journal of Pharma and Bio Sciences
 
 
    ISSN 0975-6299
www.ijpbs.net
RESEARCH ARTICLE
Int J Pharm Bio Sci Volume 7 Issue 3, 2016 (July-Sept), Pages:78 - 82
EFFECTS OF ASHWAGANDHA (WITHANIA SOMNIFERA) ROOT EXTRACT ON ARCHITECTURE OF LIVER TISSUE AGAINST GENTAMICIN INDUCED HEPATOTOXIC RATS
NAYMA SULTANA, SADIA CHOUDHURY SHIMMI, M.TANVEER HOSSAIN PARASH
DOI:
[Download PDF]
Abstract:

Prolonged use and higher doses of drugs, and some toxins produce hepatotoxicity. Ashwagandha (Withaniasomnifera) have free radical scavenging activity. It can be used as a hepatoprotective agent. This study was carried to observe the effect of Ashwagandha root extract on histology of liver against gentamicin induced hepatotoxic Wistar albino rats. Thirty-five rats were divided into control and experimental group. Control group was again subdivided into baseline control and gentamicin treated control group.Each of this group received standardized pellet for 22 consecutive days.In addition, gentamicin treated control and experimental group received gentamicin subcutaneously (100mg /kg body weight/day) for the last eight consecutive days. Experimental group also received Ashwagandha root extract (500mg/kg body weight/day; orally) for 22 consecutive days. All the animals were sacrificed on the 23rd day. Histology of liver revealed normal histological findings in 84.62% of experimental group. In conclusion, it was found that Ashwagandha may have protective effect against gentamicin induced hepatotoxicity.

Keywords: Histology, Hepatoprotective, Ashwagandha, Gentamicin
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy
Pharmaceutical Fields
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Pharmaceutics
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Novel drug delivery system
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Nanotechnology
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Pharmacology
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Pharmacognosy
© Copyright 2009-2015 IJPBS, India. All rights reserved. Specialized online journals by ubijournal. Website by Ubitech Solutions
         Home I Contact I Terms & Conditions