The aim of present study to evaluate Antioxidant and antidiabetic activity of ethanolic extract of Alternanthera ficodia (Amaranthaceae) against in streptozotocin induced diabetic rats. Plant extract were administrated orally at 400 mg/kg body weight for 15 days. The effects was compared with oral dose of 0.5mg/kg of Glibenclamide. Blood glucose levels are determination by GOD-POD kit method. The result shows the alcoholic extract of Alternanthera ficodia Linn significantly lowered the blood glucose of hyperglycemic rats. From the toxicity study it was observed that ethanolic extract of Alternanthera ficodia Linn was nontoxic up to 2000g/kg body weight and phytochemical study showed the presence of phytosterols, flavonoids and glycosides. It is concluded that Alternanthera ficodia Linn extract has significant antidiabetic activity, which lowered the fasting blood glucose level and increase body wight in Streptozotocin induced diabetic rats significantly increase antioxidant level and decreases the lipid peroxidation level and compared with untreated group.
Keywords: Anti diabetic activity, Alternanthera ficodia, streptozotocin, GOD-POD.