Cholelilithiasis or gallstone disease is a common world wide ailment mostly affecting middle aged females. Gallbladder harbouring gallstones present many histopathological findings. Gallstones are also one of the predisposing factors for adenocarcinoma of gallbladder. Seventy gallbladder specimens were obtained from patients of cholelithiasis undergoing elective cholecystectomy in a tertiary care hospital in Odisha. A prospective study was carried out to study the clinicopathological aspects of cholelithiasis, find out its risk factors and the prevalence of different type of gallstones. The resected specimens were also subjected to histopathological examination. Age, female sex, non vegetarian diet, sedentary lifestyle were identified as the main risk factors for cholelithiasis. Mixed stones were the most common variety of gallstones in our study and chronic cholecystitis was the most common associated histopathological finding.