International Journal of Pharma and Bio Sciences
 
 
    ISSN 0975-6299
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ORIGINAL RESEARCH ARTICLE
Int J Pharm Bio Sci Volume 2 Issue 1, 2011 (January - March), Pages:833-847

Formulation and evaluation of orodissolving tablet of fluoxetine using superdisintegrants

D. Indhumathi,K. Surya Prabha
DOI:
Abstract:

 Mouth dissolving tablet offers a solution for pediatrics, geriatrics; psychiatric or mentally ill people and those have difficulty in swallowing tablets/capsules resulting in improved patient compliance. The aim is to formulate fifteen formulations of fast dissolving tablet of fluoxetine using different superdisintegrants (Sodium Starch Glycolate, Croscarmellose, Crospovidone Pregelatinized starch) by wet granulation method and the tablets were evaluated for various physiochemical properties and found to be within the permissible limit. In vitro dissolution studies show the release is in the following order of superdisintegrants: Crospovidone > Pregelatinized starch > Croscarmellose > Sodium Starch Glycolate. From the study it has been found and concluded, crospovidone at a concentration of 5% w/w (F-XII) shows maximum in-vitro dissolution profile, this is also confirmed by In vivo pharmacokinetic studies, and hence it emerged as the overall best formulation hence suitable for preparing fast dissolving tablet of fluoxetine. 

Keywords: Fluoxetine, Antidepressant drug, superdisintegrants, oro-dissolving tablet, wet granulation.
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