International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 3 Issue 1
2012 (January - March)
Qualitative Analysis Of A Ciprofloxacin / Hpmc Mucoadhesive Suspension
Mucoadhesive polymeric (HPMC) suspension of Ciprofloxacin was prepared by ultrasonication and optimised with the aim to develop an oral controlled release gastro-retentive dosage form. The qualitative analysis of the formulation was performed by Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, X-ray powder diffraction (XRD) and Scanning electron microscopy (SEM). FTIR (400 cm lessThan sup greaterThan -1 lessThan /sup greaterThan to 4000 cm lessThan sup greaterThan -1 lessThan /sup greaterThan region) and Raman (140 to 2400 cm lessThan sup greaterThan -1 lessThan /sup greaterThan region) spectra were used for interpretation. XRD data of pure drug, polymer and the formulation were obtained using a powder diffractometer. The dispersion of particle was observed using SEM techniques. The results from FTIR and Raman Spectroscopic analyses suggested that in formulation, the carboxylic groups of Ciprofloxacin and hydroxyl groups of HPMC undergo chemical interaction leading to esterification and hydrogen bonding. The XRD data suggested that the retention of crystalline nature of Ciprofloxacin in the formulation could lead to increase in stability and drug loading; decrease in solubility; and delay in release of the drug from polymeric suspension with better bioavailability and penetration capacity. The SEM image analysis provided supporting evidences for homogeneous, uniformly dispersed, stable, controlled release of Ciprofloxacin suspension which would be pharmaceutically acceptable.
Subhashree Sahoo, Chandra Kanti Chakraborti And Pradipta Kumar Behera
Ciprofloxacin, HPMC, FTIR, XRD, Raman Spectroscopy, SEM
558-576