International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 3 Issue 4
2012(October - December)
A COMPARATIVE STUDY OF NEUROPROTECTIVE POTENTIAL OF INHIBITOR OF PROLYL 4-HYDROXYLASE (PHD) IN RAT MODEL OF FOCAL CEREBRAL ISCHEMIA
Cerebral stroke can decrease the blood supply to the brain at this condition stimulate the hypoxia inducible factor provide the neuroprotection in cerebral stroke. Hypoxia-inducible factor1 (HIF-1) is hetrodimer composed of HIF-1a and HIF-1b protein subunits. This transcription factor is essential for the activation of hypoxia inducible gene like erythropoietin, some glucose transporters, the glycolytic enzymes, and vascular endothelial growth factor. Because HIF-1 activation may promote cell survival in hypoxic tissues, we studied the effect of hypoxic preconditioning on HIF-1 expression in rat brain. To support the role of HIF-1 in protective preconditioning we also studied the effect of on other known HIF-1 inducer, cobalt chloride on HIF-1 expression and neuroprotection in rat brain. HIF-1a and HIF-1b protein levels were markedly increased after seven days chronic treatment of COCl lessThan sub greaterThan 2 lessThan /sub greaterThan different dose (15mg/kg, 17.5mg/kg, 20mg/kg, 22.5mg/kg) and moderately increased the brain protection, respectively compared with that of vehicle injected littermate controls.
AADITYA SINGH AND SHIV BHADRA SINGH
Hypoxia inducible factor, Prolyl hydroxylase inhibitor, Cerebral Stroke.
322-330