International Journal of Pharma and Bio Sciences
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editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 4 Issue 1
2013 (January - March)
ANTITUMORAL, ANTIOXIDANT AND ANTIMICROBIAL MOLECULES FROM COMBRETUM RUPICOLA
This investigation describes the anticancer, antioxidant and antimicrobial properties of the extracts of lessThan i greaterThan Combretum lessThan /i greaterThan lessThan i greaterThan rupicola, lessThan /i greaterThan a native plant from Northeast of Brazil. Methanolic, ethyl acetate and chloroform extracts from leaves of lessThan i greaterThan C. rupicola lessThan /i greaterThan were evaluated in relation to their potential in inhibiting the cell growth and cytotoxic properties against nine human cancer cell lines (MCF-7, NCI-ADR/RES, OVCAR-3, PC-3, HT-29, NCI-H460, 786-O, UACC-62, K-562). In addition, antioxidant activity of these extracts was measured using DPPH as radical scavenging assay and the antimicrobial activities against nine pathogens were tested by agar diffusion method. Preliminary results showed that the this plant demonstrates to have moderate activity against bacteria but, on the other side, the extracts showed significant anticancer activities against four cell lines and the most significant activity was observed against MCF-7 (65.9 µg mL lessThan sup greaterThan -1 lessThan /sup greaterThan ), highest inhibitory concentration IC lessThan sub greaterThan 50 lessThan /sub greaterThan 0.22 µg mL lessThan sup greaterThan -1 lessThan /sup greaterThan for antioxidant activity. These founds are the first scientific reports on secondary metabolites with biological activities of lessThan i greaterThan C. lessThan /i greaterThan lessThan i greaterThan rupicola lessThan /i greaterThan , suggesting the potential of this botanic species for pharmaceutical industry.
SUIKINAI NOBRE SANTOS, VANESSA N. KAVAMURA, RODRIGO F. CASTANHA, FERNANDO D. ANDREOTE, JOÃO E. CARVALHO, SONIA C. N. QUEIROZ AND ITAMAR S. MELO
Combretum rupicola, antioxidant, anticancer, antimicrobial, Fernando de Noronha Island
422-428