International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 4 Issue 1
2013 (January - March)
MICRODETERMINATION OF SILDENAFIL, TADALAFIL AND VARDENAFIL DRUGS EMPLOYED IN THE ERECTILE DYSFUNCTION THERAPY IN PHARMACEUTICAL FORMULATIONS AND URINE SAMPLES OF DIABETIC PATIENTS TYPE-II IN TAIF AREA, SAUDIA ARABIA USING ATOMIC EMISSION AND ATOMIC ABSORPTION SPECTROMETRY.
Ion – associate complexes of sildenafil, tadalafil and vardenafil hydrochlorides with [ Manganese(II) and Cobalt(II)] thiocyanates, potassium ferricyanide, sodium cobaltinitrite and ammonium reineckate were precipitated and the excess unreacted metal complex was determined. A new method using atomic emission and atomic absorption spectrometry for the determination of the above drugs in pure solutions, in pharmaceutical preparations and urine of diabetic patients type 2 was given. The drugs can be determined by the affort method in the ranges 0.56 - 104.28, 0.64 - 117.81 and 0.63 – 115.39 μg mL lessThan sup greaterThan -1 lessThan /sup greaterThan solutions of Sd, Td and Vd, respectively.
SABRY KH. MOHAMED AND NAGLAA M. SHALABY
Atomic emission, atomic absorption, ion-associate complexes, pharmaceutical analysis.
1037-1046