International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 1 Issue 2
2010 (April - June)
Non-Template Synthesis and Antimicrobial Activities of Tetraazamacrocyclic Ligands with Variable Ring Sizes
Three new macrocyclic ligands containing four aza groups have been prepared by the condensation reaction of 1-(2, 4-dihydroxyphenyl)-3-phynyl propane-1,3-dione with different diamines (1,2-diamino ethane, 1,3-diamino propane and 1,2-diamino benzene). The macrocycles prepared are "1,9-(2,4dihydroxyphenyl)-1,2-diphenyl-1,5,8,12-tetraazacyclotetradeca-1,4,z8,11-tetraene", "4,10-di(2,4dihydroxyphenyl)-2,12-diphenyl-1,5,9,13-tetraazacyclohexadeca - 1,4,9,12-tetraene" and dibenzo-[b,I]4,9-di(2,4-dihydroxyphenyl)- 2, 11 -diphenyl - 1,5,8,12-tetraazacyclotetradeca-1,4,8,11-tetraene". All the macrocyclic ligands were characterized by elemental analysis and IR, UV, NMR and mass spectral investigations and have been screened in vitro for their possible antimicrobial activity. lessThan br / greaterThan
Nirdosh Patil,Ramachandra Akkasali
Ligands, Macro cycles, Anti-microbial, Diketones
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