International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 4 Issue 3
2013 (July - September)
EVALUATION OF ANTI-DIABETIC AND ANTI-HYPERLIPIDEMIC POTENTIAL OF METHANOLIC EXTRACT OF Juniperus communis (L.) IN STREPTOZOTOCINNICOTINAMIDE INDUCED DIABETIC RATS.
lessThan i greaterThan Juniperus communis lessThan /i greaterThan (Cuppraseae), a coniferous plant widely used as traditional medicine was evaluated for the antidiabetic and antihyperlipidemic activity on Streptozotocin(STZ)-nicotinamide induced diabetic rats. The methanolic extract of lessThan i greaterThan Juniperus communis lessThan /i greaterThan (MEJC) (100mg/kg, 200mg/kg, b.w) was administered orally in diabetic group except the standard group (Glibenclamide 10mg/kg, b.w) and the fasting blood glucose levels along with the different biochemical parameters were estimated on 21 lessThan sup greaterThan st lessThan /sup greaterThan day after collecting blood through retro-orbital puncture technique. It was observed that the extract showed significant (P lessThan 0.01) reduction in blood glucose levels along with the different lipid profile parameters (with increase in HDL levels) in diabetic rats. This study demonstrated a dose dependent and significant anti-diabetic and anti-hyperlipidemic property of the extract, providing the rationale behind its use as an effective drug against type-2 diabetes.
SASWATA BANERJEE, HARIOM SINGH AND DR. TAPAN KUMAR CHATTERJEE
Antidiabetic, Antihyperlipidemic, Streptozotocin, Juniperus communis.
10-17