International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 5 Issue 4
2014 (October - December)
ANTIOXIDANT, ANTIPROLIFERATIVE ACTIVITIES AND GC-MS ANALYSIS OF METHANOL EXTRACT OF LEAVES OF HERACLEUM SPRENGELIANUM LINN.
The current study was aimed at evaluation of Antioxidant & Anti proliferative potential of the methanol extract of lessThan i greaterThan Heracleum sprengelianum lessThan /i greaterThan leaves and to elucidate its phytochemical profile using GC-MS analysis. The methanol extract of leaves of lessThan i greaterThan H. lessThan /i greaterThan lessThan i greaterThan sprengelianum lessThan /i greaterThan as screened for its antioxidant potential by dot-plot assay, DPPH radical scavenging assay and hydroxyl radical scavenging assay. Since the results were quite encouraging, it stimulated the investigators to proceed further to screen the phytochemical profiles by qualitative and quantitative methods which were further extended to thin layer chromatography, GC-MS analysis and antiproliferative activity. The result indicates that the methanol extract of leaves of lessThan i greaterThan H lessThan /i greaterThan lessThan i greaterThan . sprengelianum lessThan /i greaterThan showed significant radical scavenging activity, potent toxicity to liver cancer cells and also less toxicity to normal cells. The GC-MS result showed the presence of important active metabolites such as fatty acids and phenolic acids. Since the results are promising, lessThan i greaterThan H. sprengelianum lessThan /i greaterThan could be considered as a significant source of Antioxidant and Anti proliferative agents.
SATHAK SAMEER S.M , MANIGANDAN P, SEKAR BABU H, SIVARAJ C , SINDHU S AND ARUMUGAM P
Nilgiri Plant, DPPH, HepG2, TLC, PBMC, GC-MS.
346-356