International Journal of Pharma and Bio Sciences
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editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 6 Issue 3
2015 (July - September)
SESAMOL IN ASSOCIATION WITH FOLIC ACID SHOWS ANTI-PARKINSON EFFECT ON 6-OHDA INDUCED PARKINSONIAN ANIMAL BY REGULATING THE PARK GENES
Parkinson disease (PD) is a progressive neurodegenerative disorder which leads to motor impairment. Sesamol (SA) is a potent antioxidant, present in sesame oil and Folic acid (FA) involved in dopamine synthesis was combined together in this study and their impact on 6-OHDA induced animals was to be studied. The gene and protein expression of DJ-1, LRRK-2 and parkin were analysed by RT-PCR and western blotting. The level of dopamine was estimated by fluorimetric analysis. The presence of tyrosine hydroxylase positive (TH lessThan sup greaterThan + lessThan /sup greaterThan ) neurons was analysed by immunohistochemistry. On comparison with L-dopa, the SA and FA treated animals shows a protective effect on neurons toxicated with 6-OHDA. SA and FA suppress LRRK-2 and trigger the DJ-1 and parkin synthesis by regulating their respective gene. SA and FA have regulated dopamine level and TH lessThan sup greaterThan + lessThan /sup greaterThan neurons. Thus SA and FA may serve as a novel combined drug for treatment of PD.
KHADIRA SEREEN A AND VIJAYALAKSHMI K
Parkinson’s disease, Sesamol, Folic acid, DJ-1, LRRK-2, parkin
346-354