International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 6 Issue 3
2015 (July - September)
ANTI-LEUKEMIC STUDY OF ETHANOLIC EXTRACT OF SARGASSUM ILICIFOLIUM IN HL-60 CELL LINE INDUCED SWISS ALBINO MICE
This study was conceived to screen the anti-leukemic activity of Ethanolic extract of S lessThan i greaterThan argassum ilicifolium i lessThan /i greaterThan n HL-60 cell line induced Swiss albino mice. In order to achieve this goal, the Anti-Leukemic activity of 80% ethanolic extract (200 mg/kg) body weight of lessThan i greaterThan Sargassum ilicifolium lessThan /i greaterThan was evaluated against HL-60 tumor cell lines in mice. After the 5th day of tumor inoculation, the extract was administered daily for 14 days. Mice were sacrificed for observation of antitumor activity. The effect of lessThan i greaterThan Sargassum ilicifolium lessThan /i greaterThan on the body weight of HL-60 bearing mice and simultaneous alterations in the hematological profile and liver biochemical parameters (lipid peroxidation, GSH, SOD and Catalase) were estimated. The lessThan i greaterThan Sargassum ilicifolium lessThan /i greaterThan treated groups showed that the decrease in body weight of HL-60 bearing mice and the hematological profile reverted towards normal levels in extract treated mice. Treatment with ethanolic extract of lessThan i greaterThan Sargassum ilicifolium lessThan /i greaterThan restored the serum biochemical parameters towards normal levels and decreased the levels of lipid peroxidation and increased the levels of reduced glutathione, SOD and Catalase. The ethanolic extract of 80% w/v lessThan i greaterThan Sargassum ilicifolium lessThan /i greaterThan exhibited antitumor effect by modulating lipid peroxidation and augmenting antioxidant defense system in HL-60 cell line induced mice.
MALARKODI VELRAJ AND LENIN BABU VALLURI
Sargassum ilicifolium, 80% w/v Ethanolic extract, HL-60 cell line, Anti-leukemic activity GSH, SOD, Glutathione and Catalase
197-204