International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 6 Issue 4
2015 (October - December)
A Study Of Malondialdehyde And Lipid Profile In Pregnancy Induced Hypertension
Pregnancy Induced Hypertensive disorders are one of the commonest complication of the Pregnancy which accounts for most of the Maternal and Peri-natal Mortality and Morbidity. The diseased placenta, Lipid peroxides produced due to oxidative stress and Maternal Dyslipidemia promote a vicious cycle of events that makes a cause and effect likely to contribute to Pre-eclampsia. The subjects were of age 18-30 years, stratified in 3 groups, Non Pregnant Normal women (NN), Normal Pregnancy (NP) and Pregnancy Induced Hypertension (PIH). Pregnant cases were in their third trimester.The present study is to evaluate Serum Lipid Profile and Lipid peroxidation product Malondialdhehyde.(MDA). The results are evaluated for Mean, Standard deviation and Probability was assessed by subjecting the results to T- test, 95% (P lessThan 0.05). MDA a lipid peroxidation product was significantly increased in Normal pregnant (NP) in comparision with the Non-pregnant normal controls (NN) (P lessThan 0.05)., also there is significant rise between normal pregnancy and PIH( Preeclampsia) (P lessThan 0.005). Lipid profile parameters TG, TC showed significant rise in NP in relation to NN. A comparison of these values in PIH with NP, showed a significant rise in TG, but the TC mean values did not show statistically significant rise. The HDL-C levels in the study, showed significant decrease in PIH compared to NP. The present study shows that an abnormal lipid metabolism and high lipid peroxide concentrations may contribute to promotion of Hypertension and vascular dysfunction seen in PIH. An inclusion lipid profile in the routine ante natal investigations may warn us of cases at risk for PIH.
DR. CH. ANITA, DR. A. BHAGYALAKSHMI, DR. C. REKHAAND DR. A. SUJATHA RANI.
Malondialdhehyde, PIH, Oxidative stress. Lipid peroxidation.
167-175