International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 7 Issue 1
2016 (January - March)
POSSIBLE EFFECTIVENESS OF ACYCLOVIR AS MEDICAL TREATMENT OPTION FORĀ VULVAL WARTS
Infection with human papilloma virus is common, and associated with benign and malignant epithelial proliferations of skin and internal squamous mucosa. The mucosal human papilloma virus is oncogenic, and associated with 5 % of all cancers in men and women. A prospective study was done in Babylon Maternity and Paediatrics Teaching Hospital, for the period from February 2013 till February 2015, involved 240 women their ages ranged from 21 to 41 years. All of them were sexually active, married women, symptomatic, presented with multiple warty lesions in the vulva and eight had per-anal condylomata. History, examination ,counselling and informed consent had been performed, then 120 women treated using acyclovir cream and 120 treated by electro-diathermy, 104 from 120(87.6%) completely cleared 5 days a week for 8 weeks application compared with 110 from 120 (91.7 %) in diathermy group. Six patients from acyclovir group had less response (5%) and ten got recurrence (8.3%) while the cautery group six had recurrence(5%),two got an infection (1.66%), one had depigmentation (0.83%) and one got scarring (0.83%). Although preventive vaccines might reduce human papilloma virus associated morbidity for future generations, those with active human paapilloma virus disease still needs to be treated and treatment options either excision therapies, their aim to remove the lesion rather than target human papilloma viral infection while acyclovir target the virus itself.
DR.BUSHRA J. UMRAN
Human papilloma virus, Acyclovir.
465-473