International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 7 Issue 2
2016 (April - June)
IMPROVED RED CELL STORAGE IN DI (ISONONYL) CYCLOHEXANE 1, 2-DICARBOXYLATE (DINCH) AND DI 2 ETHYL HEXYL TERE PHTHALATE (DEHT) PLASTICISED PVC BLOOD BAGS
DEHP plasticized PVC is the preferred material for making bags for the storage of blood and blood components such as whole blood, red cells, platelets and plasma. Various studies are in progress to find alternatives for DEHP. This paper presents our studies on the use of plasticisers,di-2-ethyl hexyl terephthalate (DEHT) manufactured by M/s Eastman, U.S.A and di(isononyl)cyclohexane 1,2-dicarboxylate (DINCH) manufactured by M/s BASF, Germany, for making blood bags for the storage of RBCs. The present study is a comparative assessment of the suitability of DEHT and DINCH plasticised PVC bags for the storage of RBCs in the presence of preservative solutions AS3 and AS5. RBCs could be stored in DEHT and DINCH plasticised PVC bags for only up to 35 days in the presence of RBC preservative solution AS 5. Above this period, the hemolysis of RBCs was higher than the prescribed limit and cell swelling was higher. When RBCs were stored in 100ml AS 3 and increased volume of 125ml AS 5, the hemolysis was significantly lower and within the limits. Mean cell volume (MCV) was maintained better. Other parameters such as RBC count, Hb, Hematocrit, p H , PCO2, HCO3, Lactate, Na+, K+, Glucose etc showed comparable results. The present studies show that RBCs could be stored in DEHT and DINCH plasticised PVC bags for up to 42 days maintaining the accepted limits of hemolysis and other quality parameters using 125ml AS 5 and 100ml AS 3 additive solutions.
R.VIDYA, P.M.ASHALATHA AND C.S.BHASKARAN NAIR
Red blood cell (RBC), Non DEHP plasticizer, DINCH plasticizer, DEHT plasticizer, RBC storage.
210-217