International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 9 Issue 1
2018 (January-March)
Hepatoprotective and anti-inflammatory effects of new lectin purified from Morus nigra against lipopolysaccharideinduced oxidative stress in rats
The present study was undertaken to evaluate the protective effect of lectin purified from lessThan i greaterThan Morus nigra lessThan /i greaterThan against lipopolysaccharide induced oxidative stress in experimental rats. Exposure of rats to lipopolysaccharide caused a significant increase in the lipid peroxidation level along with corresponding decrease in the reduced glutathione and various antioxidant enzymes in liver.and increase in serum: APL and transaminases activities. Supplementation of purified lectin of lessThan i greaterThan Morus nigra lessThan /i greaterThan to lipopolysaccharide decrease in the serum the activities of AST, ALT and APL along with increase in liver GSH level and various antioxidant enzymes: glutathione peroxidase (GSH-Px), glutathione –S-transferase (GST) and catalase however the level of lipid peroxidation was increased in liver. Furthermore, no histological alterations were observed in the liver of lectin of lessThan i greaterThan Morus nigra lessThan /i greaterThan . The results clearly demonstrate the protective role of new lectin purified from lessThan i greaterThan Morus nigra lessThan /i greaterThan against LPS induced inflammatory liver in rats.
AHLEM BAHI AND YOUCEF NECIB
Antioxidant enzymes, lectin, lipopolysaccharide, anti-inflammatory activity, Morus nigra.
66-72