International Journal of Pharma and Bio Sciences
ijpbs.net
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10.22376/ijpbs.2019.10.1.p1-12
Volume 2 Issue 2
2011 (April - June)
A Review Article On "Role Of Fibroblast Growth Factor (FGF21) In Diabetes"
FGFs have diverse roles in regulating cell proliferation, migration and differentiation. Their actions are dependent on their ability to bind and activate a family of cell surface receptors with intrinsic protein tyrosine kinase activity. These receptors possess an extracellular cytoplasmic ligand-binding domain that has three immunoglobulin-like (Ig-like) regions, a hydrophobic transmembrane domain, and a discontinuous intracellular tyrosine kinase domain exhibiting a short intervening sequence. FGF-21 also improves the lipoprotein profiles by decreasing LDL-cholesterol and total cholesterol, and increasing HDL cholesterol. FGF-21 transgenic mice exhibit similar metabolic characteristics, namely reduced adiposity and resistance to diet-induced metabolic disturbances.
Ashish Kakkar
Fibroblast,diabetes,lipoprotein.
469-474