International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 2 Issue 2
2011 (April - June)
Modulation Of IgE Levels In Lead Exposed Children By Parental Cigarette Smoking, Qualyobia Governate, Egypt
Many children possessing blood lead levels (BLL) in excess of centre of disease control and prevention (CDC) guidelines ( greaterThan 10 µg/dL) exist especially in urban areas with a predominance of housing built early to mid-20 lessThan sup greaterThan th lessThan /sup greaterThan century. In addition, many children are exposed in the home to Parental tobacco smoke (PTS). The current study examined the effect of lead-exposure (BLL levels of 1-55 µg/dL) with/without concurrent PTS exposure on immune system function in 318 children aged 6-84 months from some urban areas, Qualyobia Governate, EGYPT. In this population, 62.9% of children came from smoking homes, 36.5% of children possessed BLL levels greaterThan 10 µg/dL, 51.9% of children were under 2 years of age, and the population was economically homogeneous. Multiple immune function markers including cell counts, and IgE levels were analyzed for correlation with Pb and / or PTS exposure. For children exposed to both Pb and PTS, a marginally significant relationship between IgE and BLL levels was observed (p=0.12). IgE levels increased in children with combined Pb and PTS exposure. For children exposed to Pb without PTS, decreased lymphocyte cell counts, and serum IgE levels, while granulocyte counts (%granulocytes) was increased. A statistically significant correlation between PTS and BLL levels was found.
Ragia M. Hegazy Raniah Hamdy And Hala F. Kamel
Pb-exposure, immune function, Ig E, parental tobacco smoke (PTS)
372-385