International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 2 Issue 3
2011 (July - September)
Hepatoprotective Effect Of Cassia Sophera Leaves Extract Against Paracetamol Induce Hepatic Injury In Rats.
Ethanol extract of lessThan i greaterThan Cassia sophera lessThan /i greaterThan (Caesalpiniaceae) was evaluated for hepatoprotective activity in rats. The plant extract (500 mg/kg, p.o.) showed a remarkable hepatoprotective activity against paracetamol induced hepatotoxicity as judged from the serum markers for liver damage. Paracetamol induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin and decrease in total protein. Treatment of rats with ethanol extract (500 mg/kg) significantly altered serum marker enzymes levels to near normal against paracetamol treated rats. The activity of the extract was comparable to the standard drug Liv-52 (5 ml/kg, p.o.) Histopathological changes of liver sample were compared with respective control. Results indicate that lessThan i greaterThan Cassia sophera lessThan /i greaterThan possesses hepatoprotective effect on paracetamol induced hepatotoxicity in rats.
Wankhade P.W, Nagore D. H, Kotagale N. R, Turaskar A. O and More S. M
Cassia sophera, Paracetamol, biochemical parameters and hepatotoxicity.
433-438