International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 2 Issue 4
2011 (October - December)
Protein Thiols In The Urine Of Pre-Eclampsia Patients
Hypertensive disorders of pregnancy are important causes of maternal and fetal mortality & morbidity. Pre-eclampsia is one of them. The presence of oxidative stress in pre-eclampsia is well proven fact. The thiol groups contribute most to the antioxidant status of the body. The plasma thiols were found to be decreased in patients with pre-eclampsia. The current study was designed to know the levels of such protein bound thiols in 8,12 hr urine samples and to correlate with 24 hr urine sample in pre-eclampsia patients. Serum and urine protein thiols were determined by Spectrophotometric method using dithionitrobenzoic acid (DTNB).There was significant increase in protein (p lessThan 0.01) and significant decrease in urine protein thiols (p lessThan 0.01) in 8, 12 and 24 h urine protein in pre-eclampsia patients. Among 8,12 and 24 hr urine sample in both the groups; 8 and 12 hr urine showed significant decrease in thiols compared to 24 hr urine. These results suggest that determination of total protein of 8 ,12 hour urine samples along with urine protein thiols can be a better alternative for 24 hr urine protein value in the early diagnosis of pre-eclampsia.
S.M Awanti, G.A Patil, Bhuvanendranath.H, , Santosh Jeevangi And R.B Patil
Thiols, Pre-eclampsia, proteinuria, serum protein thiols, urine protein
112-115