Int J Pharm Bio Sci Volume 2 Issue 4, 2011 (October - December), Pages:573-580
Developing In Vitro-In Vivo Correlation (Ivivc) For Trimetazidine, Indapamide And Ciprofloxacin Extended-Release Solid Oral Dosage Forms
I. E. Shohin, G. V. Ramenskayaand A. Y. Savchenko
DOI:
Abstract:
The current paper describes in vitro-in vivo correlation (IVIVC) development for extended-release solid oral dosage forms containing BCS Class I, II and III APIs: trimetazidine, indapamide and ciprofloxacin. Dissolution kinetics (in 3 media: 0.1 M or 0.01 M hydrochloric acid, acetate buffer pH 4.3, phosphate buffer pH 6.8) and pharmacokinetic properties of evaluated drugs were studied. Level B IVIVC was established for each of evaluated solid oral dosage forms, correlation coefficients (r) were 0.97, 0.94 and 0.96 for trimetazidine, indapamide and ciprofloxacin drugs, respectively.
Keywords: In vitro-in vivo correlation (IVIVC), dissolution, trimetazidine, indapamide, ciprofloxacin.
