Isonicotinoyl and nicotinoyl hydrazones bearing pyridine moiety have been synthesized by simple condensation reaction  between carbonyl compounds(1-3)  viz. 2-formyl pyridine, 2-acetylpyridine,  2- benzoylpyridine and isonicotinic acid  hydrazide (4)/nicotinic acid  hydrazide(5).  All the hydrazones are thoroughly characterized by IR, ¹H- NMR  and  mass spectral  data. Syntheses of these compounds are further confirmed by mass spectrometry. All the compounds (6-11)  were  screened for their anti-bacterial activities  against    Staphylococcus   aureus,   Bacillus subtilis,  Escherichia coli  and Salmonella typhi . Isonicotinoyl  hydrazones show more antibacterial  activity  than  the corresponding nicotinoyl  hydrazones.  Substituent  groups  -H,  -CH₃  and  C₆H₅  groups of azomethine  carbon are  varied. The  hydrazones   having  a methyl  group  attached   to  azomethine carbon atom  show more  pronounced activity.