A new public health crises threatening world with the emergence and spread of 2019 novel coronavirus [2019 nCoV] or severe acute respiratory syndrome coronavirus 2 [SARS CoV-2]. The virus originated in bats and was transmitted to humans through yet unknown intermediary animals in Wuhan, Hubei province, China in December 2019. The disease is transmitted by inhalation or contact with infected droplets and the incubation period ranges from 2 to 14 d. The symptoms are usually fever, cough, sore throat, breathlessness, fatigue, malaise among others. The disease is mild in most people; in some [usually the elderly and those with comorbidities], it may progress to pneumonia, acute respiratory distress syndrome [ARDS] and multi organ dysfunction. Many people are asymptomatic. The case fatality rate is estimated to range from 2 to 3%. Diagnosis is by demonstration of the virus in respiratory secretions by special molecular tests. Common laboratory findings include, normal/ low white cell counts with elevated C- reactive protein[CRP]. The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. The virus spreads faster than its two ancestors the SARS-CoV and Middle east respiratory syndrome coronavirus [MERS-CoV], but has lower fatality. The purpose of this review is to summarize, the available evidence on human corona virus, transmission, clinical presentation, lab investigation, diagnosis and management of new born to provide adequate information, SARS-CoV2 transmission, clinical presentation, outcomes and treatment of newborn infants to provide adequate information regarding breast feeding to neonatologists, isolation of neonates to pediatricians and obstetricians for managing such neonates and mother.

1.          GemeKSt S. B, WilsonT. Nelson textbook of pediatrics. International 21sted : In Chapter  NINE (9) Corona viruses. 2020:1743-44.

2.          Zhaos YB, et al. A new corona-virus associated with human respiratory disease in China. WuF. Nature. 2020. doi: 10.1083/s41586-020-2008-3.

3.       Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. J Adv Res. 2020;24:91-8. doi: 10.1016/j.jare.2020.03.005.

4.          McINTOSH, Perlman S. Coronaviruses, including severe respiratory syndrome and Middle East respiratory syndrome. In: Bennett JE, Dolin R, BLASERMJ, editors. douglas and Bennett: MANDELL’s principles and practices of infectious disease, 8thedn. Philadelphia Elsevier; 2015. p. 1928-36.

5.  Marino T. Chief. In: Isaacs C, editor. Viral infections and pregnancy MEDSCAPE. Available from: https://emedicine.medscape.com/article/235213-overview.

6.          Zhang Q, Cong M, Wang N, Li X, Zhang H, Zhang K, Jin M, Wu N, Qiu C, Li J. Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender: A case-control study. Medicine. 2018;97(42):e12917. doi: 10.1097/MD.0000000000012917, PMID 30335025.

7.          Zhao Z, Wang Y, Zhou Y, Ma Y, Zou W Single cell RNA expression profiling of ACE2, the putative receptor of Wuhan. NcovbioRxiv. YuZ. 2019–;2020. doi: 10.1101/2020.01.26.91998510.

8.          Al Set M. Molecularvirology. [CSpringer –Verlag Berlin Heidelberg 2013]. doi: 10.1007/978-3-642-20718-1-2.

9.          Q&A on corona viruses. World Health Organization. p. 2020; April 8, 2020. Archived fromtheoriginalon20thJanuary [cited Apr 30, 2020]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answer-hub/q-a-detail/q-a-coronaviruses.

10.       Van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, Tamin A, Harcourt JL, Thornburg NJ, Gerber SI, Lloyd-Smith JO, de Wit E, Munster VJ. MunsterVJAerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med. 2020;382(16):1564-7. doi: 10.1056/NEJMc2004973, PMID 32182409.

11.       Tanusingalin. Diagnosis of COVID 19 in children. Indian J Pract Pediatr. 2020;22(2):35-40. https://www.ijpp.in/Files/2020/ver2/Diagnosis-of-COVID-19.pdf

12.       Lai CC, Liu YH. \WangCY, Wang YH, Hsueh SC, Yen MY, et al. Asymptomatic carrier state, acute respiratory disease and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2): Facts and myths. J MicrobiolImmunolinfect. 2020.;53(3):404-412.

13.     Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020;395(10237):1607-8. doi: 10.1016/S0140-6736(20)31094-1, PMID 32386565.

14.       Gao ZC. Efficient Management of novel coronavirus pneumonia by efficient prevention and control in scientific manner. Chin J Tuberc Respir Dis. 2020;43:E001-. doi: 10.3760/cma.j.issn.1001-0939.2020.0001, PMID 32023684. Singhal T. Daignosis of COVID-19 in children. Indian J.

15.     Chawla D, Chirla D, Dalwai S, Deorari AK, Ganatra A, Gandhi A, et al. Perinatal –Neonatal Management of COVID−19 infection-Guidelines of the Federation of Obstetrics and Gynaecological Societies of India (FOGSI), National Neonatology Forum of India (NNF) and Indian Academy of Pediatrics (IAP). 1stApril. PMIDPMID. 2020. PMID 32238615.

16.       AAP News and journal gateway. April 2, 2020 [Epub]. https://www.aappublications.org/news/2020/04/02/infantcovidguidance040220

17.       ACO, The American college of Obstetricians and Gynecologists. 2020 Published 29th April 2020 [Epub]. [citedMay172020].

18.       Dhiren Gupta SAK, Bansal A, Gupta N, Patki V, Sood A, Bakuljayantparekh A. In use of personal protective Equipments During COVID 19 Pandemic In Resouce Limited Settings –The Barest Mininmum Needed. Indian J Pract Pediatr. 2020; 22(2): 83-97.

19.       Ramji S, Bhat S, Chellani H, Dutta S, Thakre R, Bhatia B. Det al. Neonat Resusc India Textbook. 3rded. 2018:5.

20.       Hui DS, Chow BK, Chu L, Ng SS, Lai ST, Gin T, Chan MT. Exhaled air dispersion and removal is influenced by isolation room size and ventilation settings during oxygen delivery via nasal cannula. Respirology. 2011;16(6):1005-13. doi: 10.1111/j.1440-1843.2011.01995.x, PMID 21605275.

21.   WHO, World Health Organization)Epub; 2020. [accessed onMay182020]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/q-a-on-covid-19-andbreastfeeding.

22.       RCPCH, Royal college of Paediatrics and Child Health [Epub: 2020.2020] [accessed on May182020].

23.  CDC, Centers for Disease Control and Prevention. Care for breastfeeding women. [cited 12/10/2020]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/hcp/care-for-breastfeeding-women.html  

24.      Ministry of Health and Family welfare Government of India. Guuidelines to be followed on detection of suspect/confirmed COVID 19 case in non COVID health facility 2020.

25.       IAP Committee on Vaccines &Immunization. ACVIP Guidelineson immunization during COVID 19 Pandemic 2020.