International Journal of Pharma and Bio Sciences
 
 
    ISSN 0975-6299
www.ijpbs.net


ORIGINAL RESEARCH ARTICLE
Int J Pharm Bio Sci Volume 12 Issue 3, 2021 (July-September), Pages:120-125

Brainstem Evoked Auditory Responses in Neonatal Hyperbilirubinemia Infants

 

Dr. Bhagya V Dr. Manjushree P and Dr. Guruprasad D
DOI: http://dx.doi.org/10.22376/ijpbs.2021.12.3.B120-125
Abstract:

Jaundice is a common finding in neonates affecting 70% of term and 80% of preterm neonates during the first week of life.  Objective  of this study is to evaluate auditory and brainstem responses in hyperbilirubinemia infants and to see if there is any statistically significant increase in latencies of wave I and V waves with rise in bilirubin levels. In  the present study we have taken 53 infants with hyperbilirubinemia>11mg% & with no other risk factors like preterm, low birth weight, birth asphyxia and age and sex matched controls who visited pediatric OPD of Bapuji Child Health Centre were evaluated using RMS EMG. EP MARK –II machine. Latencies of Waves I and V and inter-peak latency of I-V were recorded. Latency of wave V and IPL I-V were increased slightly compared to normal control subjects. Increase in the threshold leading to hearing impairment in the affected infants and complete deafness where none of the waves were recorded signify that hyperbilirubinemia is a risk factor for deafness. Since hyperbilirubinemia is a risk factor for hearing impairment, their hearing screening by BERA at the earliest and follow up will help in their earliest initiation of rehabilitation when the brain is sensitive to the development of speech & language.

 

Keywords: Hyperbilirubinemia; wave V; brainstem responses; risk factor
Full HTML:

REFERENCES 

  1. Shapiro SM. Bilirubin toxicity in the developing nervous system. Pediatr Neurol. 2003;29(5):410-21. doi: 10.1016/j.pediatrneurol.2003.09.011, PMID 14684236.
  2. Joint Committee on Infant Hearing. Pediatrics 2000. Year 2000 position statement: Principles and guidelines for early hearing detection and intervention programs;106:798-817.
  3. Kountakis SE, Skoulas I, Phillips D, Chang CYJ. Risk factors for hearing loss in neonates: A prospective study. Am J Otolaryngol. 2002;23(3):133-7. doi: 10.1053/ajot.2002.123453, PMID 12019480.
  4. Hayes D. Universal screening for infant hearing impairment. Pediatrics. 1994;94(6 pt 1):954-5; author reply 959. PMID 7971026.
  5. Sheykholeslami K, Kaga K. Otoacoustic emissions and auditory brainstem responses after neonatal hyperbilirubinemia. Int J Pediatr Otorhinolaryngol. 2000;52(1):65-73. doi: 10.1016/s0165-5876(99)00293-1, PMID 10699242.
  6. Kumar A, Dhanda R. The identification and management of deaf children. Indian J Pediatr. 1997;64(6):785-92. doi: 10.1007/BF02725500, PMID 10771921.
  7. V B, S B, Harini H, Vinod A, Dhawal S. Evaluation of auditory & brainstem responses in hyperbilirubinemic infants. J Evol Med Dent Sci. 2014;3(31, July 31):8579-8. doi: 10.14260/jemds/2014/3089.
  8. Mishra UK, Kalita J. Clinical neurophysiology: nerve conduction, electromyography, evoked potentials. 2nd ed N. Delhi: Reed Elsevier India Private Ltd; 2006. p. 425.
  9. Chadha S, Bais AS. Auditory brainstem Responses in high risk and Normal newborns. Indian J Pediatr. 1997;64(6):777-84. doi: 10.1007/BF02725499, PMID 10771920.
  10. Dennery PA, Seidman DS, Stevenson DK. Neonatal hyperbilirubinemia. N Engl J Med. 2001;344(8):581-90. doi: 10.1056/NEJM200102223440807, PMID 11207355.
  11. Baradaranfar MH, Atighechi S, Dadgarnia MH, Jafari R, Karimi G, Mollasadeghi A, Eslami Z, Baradarnfar A. Hearing status in neonatal hyperbilirubinemia by auditory brainstem evoked response and transient evoked otoacoustic emission. Acta Med Iran. 2011;49(2):109-12. PMID 21598220.
  12. Rhee CK, Park HM, Jang YJ. Audiologic evaluation of neonates with severe hyperbilirubinemia using transiently evoked otoacoustic emissions and auditory brainstem responses. Laryngoscope. 1999;109(12):2005-8. doi: 10.1097/00005537-199912000-00021, PMID 10591364.
  13. Gupta AK, Anand NK, Raj H. Evaluation of risk factors for hearing impairment in at risk neonates by brainstem evoked response audiometry (BERA). Indian J Pediatr. 1991;58(6):849-55. doi: 10.1007/BF02825449, PMID 1818882.
  14. Jafar I, Mangunatmadja I, Rohsiswatmo R, Sudjatmiko S, Suwento R, Malik SG. Brainstem evoked response auditory in healthy term neonates with hyperbilirubinemia. Paediatr Indones. 2010;50(3):144-8. doi: 10.14238/pi50.3.2010.144-8.
  15. Jiang ZD, Chen C, Liu TT, Wilkinson AR. Changes in term neonates with hyperbilirubinemia. Pediatr Neurol. 2007;37(1):35-41. doi: 10.1016/j.pediatrneurol.2007.03.006, PMID 17628220.
  16. Sharma P, Chhangani NP, Meena KR, Jora R, Sharma N, Gupta BD. Brainstem Evoked Response Audiometry (BERA) in neonates with hyperbilirubinemia. Indian J Pediatr. 2006;73(5):413-6. doi: 10.1007/BF02758564, PMID 16741327.
  17. Agarwal VK, Rakesh S, Misra PK, Kapoor RK, Malik GK. Brainstem auditory evoked response in newborn with hyperbilirubinemia. Indian J Pediatr. 1998;35:513-8.
  18. Gupta AK, Mann SB. Is auditory response a bilirubin toxicity marker? Am J Otolaryngol. 1998;19(4):232-6. doi: 10.1016/s0196-0709(98)90123-5, PMID 9692630.
  19. Shannon DA, Felix JK, Krumholz A, Goldstein PJ, Kenneth CH. Hearing screening of High –Risk Newborns with brainstem auditory Evoked potentials: A follow –up study. Pediatr. 1984;78:92-6.
  20. `1 Jiang ZD, Chen C, Liu TT, Wilkinson AR. Changes in brainstem auditory evoked response in term neonates with hyperbilirubinemia. Pediatr Neurol. 2007;37:35-41.
  21. Simmons FB. Patterns of deafness in newborns. Laryngoscope. 1980;90(3):448-53. doi: 10.1002/lary.5540900311, PMID 7189004.
  22. Chisin R, Perlman M, Sohmer H. Cochlear and brainstem responses in hearing loss following neonatal hyperbilirubinemia. Ann Otol Rhinol Laryngol. 1979;88(3 Pt 1):352-7. doi: 10.1177/000348947908800310, PMID 464527.
  23. Perlman M, Fainmesser P, Sohmer H, Tamari H, Wax Y, Pevsmer B. Auditory nerve –brainstem evoked responses in hyperbilirubinemic neonates. Pediatrics. 1983;72(5):658-64. PMID 6634269.
  24. Perlman M, Fainmesser P, Sohmer H, Tamari H, Wax Y, Pevsmer B. Auditory nerve-brainstem evoked responses in hyperbilirubinemic neonates. Pediatrics. 1983;72(5):658-64. PMID 6634269.
  25. Chisin R, Perlman M, Sohmer H. Cochlear and brainstem are responses in hearing loss following neonatal hyperbilirubinemia. Ann Otol Rhinol Laryngol. 1979;88(3 Pt 1):352-7. doi: 10.1177/000348947908800310, PMID 464527.
  26. Stockard JJ, Rossiter VS. Clinical and pathological correlates of brainstem auditory response abnormalities. Neurology. 1977;27(4):316-25. doi: 10.1212/wnl.27.4.316, PMID 557773
[Download PDF]
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy
Pharmaceutical Fields
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Pharmaceutics
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Novel drug delivery system
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Nanotechnology
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Pharmacology
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Pharmacognosy
© Copyright 2009-2015 IJPBS, India. All rights reserved. Specialized online journals by ubijournal. Website by Ubitech Solutions
         Home I Contact I Terms & Conditions