International Journal of Pharma and Bio Sciences
 
 
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ORIGINAL RESEARCH ARTICLE
Int J Pharm Bio Sci Volume 13 Issue 1, January - March, Pages:52-59

Evaluation Of Combination Effects Of Some Selected Plants On Diabetes Mellitus

Prasad B and Roshan S
DOI: http://dx.doi.org/10.22376/ijpbs.2022.13.1.P52-59
Abstract:

Diabetes mellitus (DM) is a syndrome characterized by chronic hyperglycemia and disturbances of carbohydrate, fat and protein metabolism associated with absolute or relative deficiencies in insulin secretion and/or insulin action. Despite considerable progress in the treatment of diabetes by oral hypoglycemic agents, search for newer drugs continues, because the existing synthetic drugs have several limitations. In recent times, there has been a renewed interest in the plant remedies. The aim and objective of the study is evaluation of anti diabetic activity of individual plant extracts and combination of polyherbal extraction. Methanolic extraction of Salacia oblonga (MESO), Salacia roxburghii (MESR), Lagerstroemia parviflora (MELP), polyherbal methanolic extraction (PHME) studied for anti-diabetic activity in alloxan induced hyperglycaemic rats at a dose of 400mh/kg b.w.  The obtained  results of phytochemical investigation reveals the presence of alkaloids, flavonoids, saponins, tannins, steroids, triterpinoids, carbohydrates and glycosides, the methanolic extracts showed significant reduction of blood glucose levels in alloxon induced rats. The results showed that the extracts displayed significant activities when treated in combination, hence poly herbal extraction were suggested having anti diabetic properties.

Keywords: Salacia oblonga, Salacia roxbhurgii, Lagerstroemia parviflora, Anti-diabetic activity
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References

  1. Barar F. Essential of pharmacotherapeutics. 6th ed, S. Chand and Company Ltd.
  2. Ahmed MF. Anti diabetic Activity of Vinca rosea Extracts in alloxan-Induced Diabetic Rats. Int J Endocrinol. 1995:1-6.
  3. Aiman R. Recent research in indigenous anti-diabetic medicinal plants: an overall assessment. Ind J Physiol Pharmacol. 1970;14:95-75.
  4. Dinesh Puri, Mohapatra T. New oral hypoglycemic agents: merits and demerits. Ind J Clinpract. 1997;7:34-56.
  5. Ratnakar P, Murthy PS. On mechanism of action of water extract of garlic and two partially purified proteins. Ind J Clin Biochem. 1996;11:97-4.
  6. Jarald E, Joshi SB, Jain DC. Diabetes and herbal medicines. Iran J Pharmacol Ther. 2008;1:97-106.
  7. Rosalie IO, EL E. Anti diabetic potentials of common herbal plants and plant products: A glance. Int J Herb Med. 2019;4:90-7.
  8. Ghorbanifar A. Best herbs for managing diabetes: a review of clinical studies.Brazillian journal of pharmaceutical sciences. 2013;49:1-9.
  9. Wais M, Nazish I, Samad A, Beg S, Abusufyan S, Ajaj SA, Aqil M. Herbal Drugs for Diabetic Treatment:an updated review of patents. Recent Pat Antiinfect Drug Discov. 2012;7(1):53-9. doi: 10.2174/157489112799829701, PMID 22353000.
  10. Vijayalakshmi N, Anbazhagam M, Arumugam K. Medicinal plants for diabetes used by the people of thirumoorthy hills region of Western Ghats. Int J Curr Micro Boil Appl Sci. 2014;3:405-10.
  11. Nigam V, Nambiar VS. Therapeutic potential of Aegle marmelos correa leaves as an antioxidant and anti diabetic agent: a review. Int J Life Sci Pharm Res. 2015;6(3):1-9.
  12. Kushwaha PS, Singh AK, Keshari AK, Maity S, Saha S. An updated review on the phytochemistry, pharmacology, and clinical trials of Salacia oblonga. Pharmacogn Rev. 2016;10(20):109-14. doi: 10.4103/0973-7847.194046, PMID 28082793.
  13. Vyas N, Mehra R, Makhija R. Salacia - The new multi-targeted approach in diabetics. Ayu. 2016;37(2):92-7. doi: 10.4103/ayu.AYU_134_13, PMID 29200746.
  14. Anonymous. The Indian pharmacopoeia. Govt. of India publication, New Delhi. Vols. 947-950; 1996.
  15. Harborne JB: Photochemical Methods. A Guide to Modern Techniques of Plant Analysis.2nd edition, Chapman & Hall, London, 1973, p. 279.
  16. Sravan Kumar B. Anti diabetic activity of stem bark of Neolamarckia cadamba in alloxan induced diabetic rats. IJPT. 2010;2(2):314-24.
  17. Chaudhuri M. Limitations of glucose oxidase method of glucose estimation in jaundiced neonates. IJEB.2006;44:254-5.
  18. Basak A. Development of rapid and inexpensive plasma glucose estimation by two point kinetic method based on glucose oxidase-peroxidase enzymes. Indian J Clin Biochem. 2007;22(1):156-60. doi: 10.1007/BF02912902, PMID 23105673.
  19. Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen receptor. Ann Clin Biochem. 2008;6:24-7.
  20. Gangadevi T. Anti – hyperglycemic activity of Cassia kleinii Leaf extract in glucose Fed Normal Rats and Alloxan Induced Diabetic Rats. Indian J Pharmacol. 2002;34:409-15.
  21. Seetharam YN, Chalageri G, Setty SR, Bheemachar. Hyperglycemic Activity of Abutilon indicum leaf extracts in rats. Fitoterapia. 2002;73(2):156-59. doi: 10.1016/S0367-326X(02)00015-1.
  22. Babu V. Antihyperglycaemic Activity of Cassia Kleinil, bark Extract in Glucose Fed Normal Rat &alloxan Induced Diabetic Rats.  IJPRD.2007;3:409-15.
  23. Syed M. Anti-diabetic activity of Terminalia catappa Linn. Leaf Extracts Alloxan-Induced Diabet Rats IJPT. 2005;4:36-9.
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