Abnormal uterine bleeding (AUB) is a frequently encountered problem for which women used to have gynecological consultation. Endometrial aspiration cytology (EAC) is an acceptable and valuable diagnostic procedure for screening the endometrial status. The study was conducted to evaluate the utility of EAC in women with AUB, and to compare cytological findings were compared with the histopathological findings. Cross-sectional cohort study done at different districts of Gujarat from October 2011 to June 2021. A total of 1405 patients presenting with AUB were subjected to EAC using a 4?mm Karman’s cannula. We have also performed endometrial dilation and curettage. The cytology smears were prepared and evaluated for various cytomorphological features. The cytological diagnoses made were compared with the histopathological diagnosis to obtain sensitivity, specificity, and diagnostic accuracy of EAC. Statistical analyses were performed using the IBM SPSS (Statistical package for the Social Sciences v15.0) and Microsoft Excel 2007 software. EAC showed a sample adequacy of 96.65% in relation to 98.15% for histopathology. EAC showed a sensitivity of 98% and 100% for diagnosing benign and malignant conditions, respectively. There was a good correlation between cytological and histopathological diagnosis (κ = 0.643). EAC is a cost effective and least invasive procedure for the primary investigation & work up of women with AUB.
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