International Journal of Pharma and Bio Sciences
    ISSN 0975-6299

Int J Pharm Bio Sci Volume 13 issue 2, April - June, Pages:40-50

Antioxidant Potential, Acute Toxicity Profile and Bioavailability Studies of Water Soluble Analogue of Curcumin

Dr. Mohammad Haneef, Mr. Viney Budhiraja and Mr. Paras Budhiraja

Curcumin, a bright yellow colored phytochemical is the principal and active ingredient - curcuminoids present in the plant Curcuma longa which belonging to the family Zingiberaceae. Curcumin has said to be metabolized in intestine and liver and metabolizes to form glucuronide and sulfate conjugate thus exhibiting its restricted oral bioavailability. It has been studied till Phase-II clinical study, but its bioavailability is still an issue (Biological Classification System-IV {BCS-Class-IV}). Nonetheless, curcumin can be successfully formulated for oral administration, but care needs to be taken with formulation design to ensure consistent bioavailability. There are numerous studies in support of excellent antioxidant activity, safe toxicity profile and bioavailability of conventional and modulated curcumin. The aim of the present study was to investigate the antioxidant potential, acute toxicity profile and bioavailability of water soluble part of curcumin. Objective of research is to determine the antioxidant potential and acute toxicity of aqueous soluble part of curcumin .

Keywords: Curcumin, Water soluble curcumin, Bioavailability, Solubility, Dissolution, Toxicity
Full HTML:



1. Priyadarsini KI. The chemistry of curcumin: from extraction to therapeutic agent. Molecules. 2014;19(12):20091-112. doi: 10.3390/molecules191220091, PMID 25470276.

2.         Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195-218. doi: 10.1208/s12248-012-9432-8, PMID 23143785.

3.         Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003;23(1A):363-98. PMID 12680238.

4.         Lestari ML, Indrayanto G. Curcumin. Profiles Drug Subst Excip Relat Methodol. 2014;39:113-204. doi: 10.1016/B978-0-12-800173-8.00003-9, PMID 24794906.

5.         Mahady GB, Pendland SL, Yun G, Lu ZZ. Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. Anticancer Res. 2002;22(6C):4179-81. PMID 12553052.

6.         Reddy RC, Vatsala PG, Keshamouni VG, Padmanaban G, Rangarajan PN. Curcumin for malaria therapy. Biochem Biophys Res Commun. 2005;326(2):472-4. doi: 10.1016/j.bbrc.2004.11.051, PMID 15582601.

7.         Vera-Ramirez L, Pérez-Lopez P, Varela-Lopez A, Ramirez-Tortosa M, Battino M, Quiles JL. Curcumin and liver disease. BioFactors. 2013;39(1):88-100. doi: 10.1002/biof.1057, PMID 23303639.

8.         Wright LE, Frye JB, Gorti B, Timmermann BN, Funk JL. Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer. Curr Pharm Des. 2013;19(34):6218-25. doi: 10.2174/1381612811319340013, PMID 23448448.

9.         Basnet P, Skalko-Basnet N. Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules. 2011;16(6):4567-98. doi: 10.3390/molecules16064567, PMID 21642934.

10.       Lao CD, Ruffin MT, Normolle D, Heath DD, Murray SI, Bailey JM, Boggs ME, Crowell J, Rock CL, Brenner DE. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 2006;6:10. doi: 10.1186/1472-6882-6-10, PMID 16545122.

11.       Malik SN, Canaham DH, Gouda MW. Effect of surfactants on absorption through membranes III: Effects of dioctyl sodium sulfosuccinate and poloxalene on absorption of a poorly absorbable drug, phenolsulfonphthalein, in rats. J Pharm Sci. 1975;64(6):987-90. doi: 10.1002/jps.2600640620, PMID 1133757.

12.       Reddy RK, Khalil SA, Gouda MW. Effect of dioctyl sodium sulfosuccinate and poloxamer 188 on dissolution and intestinal absorption of sulfadiazine and sulfisoxazole in rats. J Pharm Sci. 1976;65(1):115-8. doi: 10.1002/jps.2600650126, PMID 1255414.

13.       El-Badry M, Fathy M. Enhancement of the dissolution and permeation rates of meloxicam by formation of its freeze-dried solid dispersions in polyvinylpyrrolidone K-30. Drug Dev Ind Pharm. 2006;32(2):141-50. doi: 10.1080/03639040500465983, PMID 16537195.

14.       Frizon F, Eloy JdO, Donaduzzi CM, Mitsui ML, Marchetti JM. Dissolution rate enhancement of loratadine in polyvinylpyrrolidone K-30 solid dispersions by solvent methods. Powder Technol. 2013;235:532-9. doi: 10.1016/j.powtec.2012.10.019.

15.       Shelat DY, Acharya SR. Cur-Ca-Thione: A Novel curcumin concoction with enhanced water solubility and Brain Bio-Availability. Int J Pharm Pharm Sci;8(12):265-70. doi: 10.22159/ijpps.2016v8i12.15093.

16.       Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4(6):807-18. doi: 10.1021/mp700113r, PMID 17999464.

17.       Shelat P, Mandowara V, Gupta D, Patel S. Formulation of curcuminoid loaded solid lipid nanoparticles in order to improve oral bioavailability. Int J Pharm Pharm Sci. 2015;7:7-11.

18.       Leung MH, Kee TW. Effective stabilization of curcumin by association to plasma proteins: human serum albumin and fibrinogen. Langmuir. 2009;25(10):5773-7. doi: 10.1021/la804215v, PMID 19320475.

19.       Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY, Lin JK. Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal. 1997;15(12):1867-76. doi: 10.1016/s0731-7085(96)02024-9, PMID 9278892.

20.       Kurmi R, Mishra D, Jain D. Solid dispersion: a novel means of solubility enhancement. Crit Rev. 2016;3:1-8.

21.       OECD guideline for testing of chemicals, Test No. 423. Acute oral toxicity- acute toxic class method; adopted on 17th December, 2001.

22.       United Nations. Globally harmonised system of classification and labelling of chemicals (GHS). 7th rev ed. Geneva and New York; 2017.

23.       Compendium of Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA). J Clim Change. 2018.

24.       Shankar TN, Shantha NV, Ramesh HP, Murthy IA, Murthy VS Bhavani et al. Toxicity studies on turmeric (Curcuma longa): acute toxicity studies in rats, guineapigs & monkeys. Indian J Exp Biol. 1980;18(1):73-5. PMID 6772551.

25.       Aggarwal ML, Chacko KM, Kuruvilla BT. Systematic and comprehensive investigation of the toxicity of curcuminoid-essential oil complex: A bioavailable turmeric formulation. Mol Med Rep. 2016;13(1):592-604. doi: 10.3892/mmr.2015.4579, PMID 26648561.

26.       Gopi S, Jacob J, Mathur KY. Acute and subchronic oral toxicity studies of hydrogenated curcuminoid formulation ’CuroWhite’ in rats. Toxicol Rep. 2016;3:817-25. doi: 10.1016/j.toxrep.2016.10.007, PMID 28959609.

27.       Sharma A, Jain CP. Preparation and characterization of solid dispersions of carvedilol with PVP K30. Res Pharm Sci. 2010;5(1):49-56. PMID 21589768.

28.       Ghumre, Priti B., Sujata S. Bote, Shweta R. Kotgir, Apeksha B. Korde, Bhagyashri S. Bhosale, and Rahul B. Chaudhari. "SOLUBILITY ENHANCEMENT TECHNIQUE–A REVIEW." (2021).



[Download PDF]
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy
Pharmaceutical Fields
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Pharmaceutics
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Novel drug delivery system
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Nanotechnology
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Pharmacology
Welcome to IJPBS,Pharmaceutics, Novel, drug, delivery, system, Nanotechnology, Pharmacology, Pharmacognosy Pharmacognosy
© Copyright 2009-2015 IJPBS, India. All rights reserved. Specialized online journals by ubijournal. Website by Ubitech Solutions
         Home I Contact I Terms & Conditions