Ferrous sulphate has poor bioavailability in the upper Gastrointestinal tract and low solubility in an acidic medium. To prolong the dosage form in the stomach and increase the residence time, the drug is used as a new drug delivery system as a matrix tablet of a Floating drug delivery system. The Floating Drug Delivery System(FDDS) has many more advantages for increasing drug absorption and enhancing bioavailability. Iron is a necessary element of our body. The marketed products have less or incomplete absorption because of increased excretion of drugs or bowel transport in GIT such as constipation, black stools and diarrhoea. In this research work, ascorbic acid added to the formulation can increase iron absorption. Lycopene is an antioxidant as a supplement with ferrous sulphate. Ten formulations were formulated with different retarding polymers by direct compression method. Citric acid and Sodium bicarbonate were producing effervescent. Pre-compression and post-compression evaluation tests were done for all the designed tablets. From the in vitro release, formulation 5 (F5) showed the highest release percentage at 24 hours. The optimized formulation 5 (F5) was subjected to various release kinetics, and formulation 5 (F5) was found to obey zero order kinetics more over the peppas model was 0.45

1. Hirtz J. The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation. Br J Clin Pharmacol. 1985;19(S2):77S-83S. doi: 10.1111/j.1365-2125.1985.tb02746.x.
2. Baumgartner S, Kristl J, Vrecer F, Vodopivec P, Zorko B. Optimisation of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm. 2000;195(1-2):125-35. doi: 10.1016/s0378-5173(99)00378-6, PMID 10675690.
3. Baratam SR, J V. Formulation and evaluation of floating matrix tablets of levofloxacin hemihydrate using hydroxypropyl methylcellulose K4m to treat Helicobacter pylori infection. Asian J Pharm Clin Res. 2018;11(6):148-51. doi: 10.22159/ajpcr.2018.v11i6.20296.
4. Shaha SH, Patel JK, Pundarikakshudu K. An overview of a gastroretentive floating drug delivery system. Asian J Pharm Sci. 2009;4:65-80.
5. Rouge N, Allémann E, Gex-Fabry M, Balant L, Cole ET, Buri P, et al. Comparative pharmacokinetic study of a floating multiple-unit capsule, a high-density multiple-unit capsule and an immediate-release tablet containing 25 mg atenolol. Pharm Acta Helv. 1998;73(2):81-7. doi: 10.1016/s0031-6865(97)00050-2, PMID 9700936.
6. Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Release. 2000;63(3):235-59. doi: 10.1016/s0168-3659(99)00204-7, PMID 10601721.
7. Najafia RB, Saghaeib L, Babaeimehrc Taher. Preparation and Pharmaceutical Evaluation of Ferrous Sulfate and ascorbic acid Floating Matrix Tablet for Prevention of anemia. J Rep Pharm Sci. 2012;1(2):72-80.
8. Zhang D, Carpenter CE, Mahoney AW. A mechanistic hypothesis for meat enhancement of nonheme iron absorption: stimulation of gastric secretions and iron chelation. Nutr Res. 1990;10(8):929-35. doi: 10.1016/S0271-5317(05)80056-9.
9. Jacobs A, Rhodes J, Peters DK, Campbell H, Eakins JD. Gastric acidity and iron absorption. Br J Haematol. 1966;12(6):728-36. doi: 10.1111/j.1365-2141.1966.tb00159.x, PMID 5925454.
10. Powell JJ, Whitehead MW, Lee S, Thompson RPH. Mechanisms of gastrointestinal absorption: dietary minerals and the influence of beverage ingestion. Food Chem. 1994;51(4):381-8. doi: 10.1016/0308-8146(94)90189-9.
11. Brise H, Hallberg L. Effect of ascorbic acid on iron absorption. Acta Med Scand Suppl. 1962;376:51-8. doi: 10.1111/j.0954-6820.1962.tb18683.x, PMID 13873150.
12. Hunt JR, Gallagher SK, Johnson LK. Effect of ascorbic acid on apparent iron absorption by women with low iron stores. Am J Clin Nutr. 1994;59(6):1381-5. doi: 10.1093/ajcn/59.6.1381, PMID 8198064.
13. Sungthongjeen S, Paeratakul O, Limmatvapirat S, Puttipipatkhachorn S. Preparation and in vitro evaluation of a multiple-unit floating drug delivery system based on gas formation technique. Int J Pharm. 2006;324(2):136-43. doi: 10.1016/j.ijpharm.2006.06.002, PMID 16828997.
14. Bansal M, Walia MK, Singh G, Harikumar SI. Formulation and evaluation of lycopene loaded colloidal microparticles gel, ijap. 2019;11(6):165-70.
15. Patel C, Patel L, Prajapati S. Polymers for floating drug delivery system2011; January 1, 2011.
16. Dey S, Dutta S, Mazumder B. Formulation and evaluation of floating matrix tablet of atenolol for gastro retentive drug delivery. Int J Pharm Pharm Sci. 2012;4:433-7.
17. El-Zahaby SA, Kassem AA, El-Kamel AH. Design and evaluation of gastroretentive levofloxacin floating mini-tablets-in-capsule system for eradication of Helicobacter pylori. Saudi Pharm J. 2014;22(6):570-9. doi: 10.1016/j.jsps.2014.02.009, PMID 25561871.
18. Jagdale SC, Agavekar AJ, Pandya SV, Kuchekar BS, Chabukswar AR. Formulation and evaluation of gastroretentive drug delivery system of propranolol hydrochloride. AAPS PharmSciTech. 2009;10(3):1071-9. doi: 10.1208/s12249-009-9300-8, PMID 19672719.
19. Singh K, Jain SK, Razdan K, Singh H, Sahajpal NS, Singh H et al. Formulation and Evaluation of ferrous ascorbate Floating Tablets for the treatment of anaemia. Drug Deliv Lett. 2019;9(4):299-307. doi: 10.2174/2210303109666190708151137.
20. Awasthi R, Kulkarni GT. Development of novel gastroretentive floating particulate drug delivery system of gliclazide. Curr Drug Deliv. 2012;9(5):437-51. doi: 10.2174/156720112802650716, PMID 22920574.
21. Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 2010;67(3):217-23. PMID 20524422.
22. Bandameedi R, P Sp. Formulation and Evaluation of Gastroretentive Floating Bioadhesive Tablets of Hydrochlorthiazide. Asian J Pharm Clin Res. 2017;10(5):150-5. doi: 10.22159/ajpcr.2017.v10i5.17137.
23. Shivhare UD, Chilkar PM, Bhusari KP, Mathur VB. Formulation and evaluation of floating matrix tablet for controlled drug release. Dig J Nanomater Biostructures. 2011;6(4):1841-50.
24. Indian pharmacopoeia 1996. Vol. 2. Ghaziabad: The Indian Pharmacopoeia Commission. p. 734.
25. Wells JI. In: Swarbick J, Boylan JC, editors. Encyclopedia of pharmaceutical technology. 2nd ed. Vol. X. New York: Marcel Dekker; 1996. p. 411.
26. Rahman Z, Ali M, Khar RK. Design and evaluation of bilayer floating tablets of captopril. Acta Pharm. 2006;56(1):49-57. PMID 16613734.
27. Reddy KR, Mutalik S, Reddy S. Once-daily sustained-release matrix tablets of nicorandil: formulation and in vitro evaluation. AAPS PharmSciTech. 2003;4(4):E61. doi: 10.1208/pt040461. PMID 15198556.
28. Sambamoorthy et al. formulation and evaluation of floating matrix tablets of telmisartan IJCTPR. Vol. 2(6); 2014. p. 494-505.