Psoriasis is a chronic autoimmune condition that causes rapid skin cell buildup and surface scaling. Psoriatic scales typically appear as thick, red rashes with whitish-silver scales, with this condition typically causing inflammation and redness around the scales. Quercetin has been used to treat many skin disorders in combination with other flavonoid drugs. The novelty of this research describes a lipophilic drug (Quercetin) enclosed in hydrogel for topical application without any combination of drugs. This research aimed to design and optimize the Quercetin-loaded nanogel and evaluate its efficacy by drug loading, entrapment efficiency, and particle size. Quercetin-loaded nanogels have many advantages over other formulations due to their high drug-loading capacity and temporal drug release, making them a convenient delivery system for topical use. The optimized particle size was found to be 34.68 nm, and the Polydispersity index (PDI) was 0.208 with an entrapment efficiency of 6.90 %, which has ideal ranges for topical applications. Studies on homogeneity and extrudability have shown that the nanogel was both homogenous and simple to extrude. Based on the pH data, all the formulation is between 6.1 and 6.9, which is ideal for skin pH. ANOVA analysis implies the quadratic model is significant for studying nanogel formulation. The unique features and low toxicity of nanogel make the nanogel compatible with topical drug delivery.

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