Functional foods, which are medicinal, provide health benefits beyond its energy and essential nutrients. The proposed literature review highlights nutraceutical advancements in sports physiology and performance. The review focuses on recent innovations and applications of nutraceutical formulation in the sports industry. The scientific-based evidence and reports presented were elucidated from Advance Search, Elsevier, NCBI, and peer-reviewed journals. Literature documents have revealed the emerging effect of polyphenols and flavonoids in muscle performance, especially Quercetin, Resveratrol, and green tea catechins, which also protect muscle cardiovascular fibers against oxidative stress induced by ischemia. It is widely clear that athletes do extensive exercises and good nutrition to provide maximum results. Nutraceuticals and dietary supplements are now commonly used to enhance and improve the health and performance of athletes. This has triggered the sale of nutraceuticals in the market and stores and gyms are selling hundreds of supplements. These nutritional supplements are usually claimed to improve strength, performance, and stamina, help build lean muscle, and burn excess fat. The current understanding of muscle damage and pain couples muscle damage and associated pain with generating reactive oxygen species (ROS), oxidative stress, and inflammation. Mounting bodies of evidence have substantiated the utility of several plants, plant extracts, and phytochemicals as Nutripharmacotherapeutic interventions to scavenge ROS and ameliorate inflammation. The medicinal herbs have shown promising therapeutic effects in supporting sports performance and helping manage sports injuries.

1. Daliri EB, Lee BH. Current trends and future perspectives on functional foods and nutraceuticals. Beneficial microorganisms in food and nutraceuticals. 2015:221-44.
2. NavaneethaKrishnan S, Rosales JL, Lee KY. ROS-mediated cancer cell killing through dietary phytochemicals. Oxidative medicine and cellular longevity. 2019 May 14;2019.
3. Karati D, Varghese R, Mahadik KR, Sharma R, Kumar D. Plant bioactives in the treatment of inflammation of skeletal muscles: a molecular perspective. Evidence-Based Complementary and Alternative Medicine. 2022 Jul 20;2022.
4. Hoadley JE. US regulation of functional foods. InFunctional Foods 2011 Jan 1 (pp. 41-63). Woodhead Publishing.
5. Arent SM, Pellegrino JK, Williams CA, DiFabio DA, Greenwood JC. Nutritional supplementation, performance, and oxidative stress in college soccer players. The Journal of Strength & Conditioning Research. 2010 Apr 1;24(4):1117-24.
6. Lopresti AL. The effects of psychological and environmental stress on micronutrient concentrations in the body: a review of the evidence. Advances in Nutrition. 2020 Jan 1;11(1):103-12.
7. Casazza GA, Tovar AP, Richardson CE, Cortez AN, Davis BA. Energy availability, macronutrient intake, and nutritional supplementation for improving exercise performance in endurance athletes. Current sports medicine reports. 2018 Jun 1;17(6):215-23.
8. Su LY, Huang WC, Kan NW, Tung TH, Huynh LB, Huang SY. Effects of resveratrol on muscle inflammation, energy utilisation, and exercise performance in an eccentric contraction exercise mouse model. Nutrients. 2023 Jan 3;15(1):249.
9. Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food and chemical toxicology. 2007 Nov 1;45(11):2179-205.
10. Methenitis S, Stergiou I, Antonopoulou S, Nomikos T. Can exercise-induced muscle damage be a good model for the investigation of the anti-inflammatory properties of diet in humans? Biomedicines. 2021 Jan 5;9(1):36.
11. Chen X, Ji Y, Liu R, Zhu X, Wang K, Yang X, Liu B, Gao Z, Huang Y, Shen Y, Liu H. Mitochondrial dysfunction: roles in skeletal muscle atrophy. Journal of Translational Medicine. 2023 Jul 26;21(1):503.
12. Carlsohn A, Braun H, Grosshauser M, Koenig D, Lampen A, Mosler S, Niess A, Oberritter H, Schaebethal K, Schek A, Stehle P. Minerals and vitamins in sports nutrition. Position of the working group sports nutrition of the German Nutrition Society (DGE). Ernahrungs Umschau. 2019 Dec 1;66(12):250-7.
13. Vitale K, Getzin A. Nutrition and supplement update for the endurance athlete: review and recommendations. Nutrients. 2019 Jun 7;11(6):1289.
14. Teodoro AJ. Bioactive compounds of food: their role in the prevention and treatment of diseases. Oxidative medicine and cellular longevity. 2019 Mar 11;2019.
15. Tipoe GL, Leung TM, Hung MW, Fung ML. Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection. Cardiovascular & Haematological Disorders-Drug Targets (Formerly Current Drug Targets-Cardiovascular & Hematological Disorders). 2007 Jun 1;7(2):135-44.
16. Tejada S, Manayi A, Daglia M, F Nabavi S, Sureda A, Hajheydari Z, Gortzi O, Pazoki-Toroudi H, M Nabavi S. Wound healing effects of curcumin: A short review. Current pharmaceutical biotechnology. 2016 Sep 1;17(11):1002-7.
17. Maheshwari M. Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model. Journal of Functional Foods. 2010 Jan 1;2(1):60-5.
18. Nosrati?Oskouie M, Aghili?Moghaddam NS, Tavakoli?Rouzbehani OM, Jamialahmadi T, Johnston TP, Sahebkar A. Curcumin: A dietary phytochemical for boosting exercise performance and recovery. Food Science & Nutrition. 2022 Nov;10(11):3531-43.