10.22376/ijpbs.2019.10.1.p1-12 Volume 1 Issue 4 2010 (October - December) In order to create novel antidepressants without oxidative tissue damage, less side effects and good bioavailability, structurally simple selective serotonin reuptake inhibitors with a isobenzofuran skeleton were designed based on the SAR of the target molecule - Citalopram and Talopram. As a result, designed molecules obey the Lipinski rule of 5 and also give moderate to good druglikness score.  C. Iyyappan,C. Praveen,K. Hemalatha,K. Girija Isobenzofuran, Ligand based drug design, Selective Serotonin Reuptake Inhibitor, Citalopram, Talopram, Druglikeness 323-329