10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 4 2011 (October - December) Due to ever growing need of lead modification and repositioning of various drug molecules; lessThan i greaterThan in-silico lessThan /i greaterThan drug design techniques are being considered as the most economical and high through put screening methods. The present study shows not only the importance of Isatins as antimicrobials but also tries to identify and filter useful data pertaining to structural peculiarities which are in turn useful for pharmacological and medicinal predictions. From the present study, it is observed that all the compounds are predicted to have oral bioavailability, considerable chances of human intestinal absorption, and has no BBB penetrations. Available LD lessThan sub greaterThan 50 lessThan /sub greaterThan , LC lessThan sub greaterThan 50 lessThan /sub greaterThan , LOAEL values suggest that the molecules are safe for the further evaluations. Also from the available data generated by lessThan i greaterThan in-silco lessThan /i greaterThan experimentation, it is predicted that compound 3B have considerable pharmacological profile for further developments. Judy Jays, Ankit Rochani, Amit Kumar, B.V. Suma, CHSVenkataramana And V. Madhavan In-silico ADME, Isatin, In-silico toxicity studies. 25-33