10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 4 2011 (October - December) lessThan b greaterThan lessThan i greaterThan Objective: - lessThan /i greaterThan lessThan /b greaterThan To evaluate antidepressant like activity of tapentadol in Swiss albino mice. lessThan b greaterThan lessThan i greaterThan Materials and Methods: - lessThan /i greaterThan lessThan /b greaterThan Tapentadol was administered at three different doses (10, 20 and 40mg/kg i.p) once daily for 7 days to Swiss albino mice of either sex. The immobility period of control and drug treated mice were recorded in Forced swim test (FST). The antidepressant activity of tapentadol was compared to that of fluoxetine (20mg/kg i.p), administered for 7 days. A locomotor activity test was carried out to ascertain whether the antidepressant effect of tapentadol included general CNS stimulation. lessThan b greaterThan lessThan i greaterThan Results: - lessThan /i greaterThan lessThan /b greaterThan Tapentadol produced significant antidepressant activity at all the 3 doses, as indicated by reduction in immobility times as compared to control. The efficacy of tapentadol at doses of 20 and 40mg/kg was comparable with that of fluoxetine. Tapentadol at 10mg/kg dose showed significantly less antidepressant activity compared to fluoxetine. Tapentadol did not show significant effect on locomotor activity of mice. lessThan b greaterThan lessThan i greaterThan Conclusion: lessThan /i greaterThan lessThan /b greaterThan The result of the present study indicates antidepressant like activity of tapentadol. B.Ramanath Royal And Narayan Pandurang Burte Antidepressant, Forced swim test, locomotor activity, tapentadol. 442-447