<?xml version="1.0" encoding="utf-8"?>
<Journal>
<Journal-Info>
<name>International Journal of Pharma and Bio Sciences</name>
<website>ijpbs.net</website>
<email>editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com</email>
</Journal-Info>
<article>
<article-id pub-id-type='other'>10.22376/ijpbs.2019.10.1.p1-12</article-id>
<issue_number>Volume 2 Issue 4</issue_number>
<issue_period>2011 (October - December)</issue_period>
<title>Developing In Vitro-In Vivo Correlation (Ivivc) For Trimetazidine, Indapamide And Ciprofloxacin Extended-Release Solid Oral Dosage Forms </title>
<abstract>The current paper describes  lessThan i greaterThan in vitro-in vivo lessThan /i greaterThan  correlation (IVIVC) development for extended-release solid oral dosage forms containing BCS Class I, II and III APIs: trimetazidine, indapamide and ciprofloxacin. Dissolution kinetics (in 3 media: 0.1 M or 0.01 M hydrochloric acid, acetate buffer pH 4.3, phosphate buffer pH 6.8) and pharmacokinetic properties of evaluated drugs were studied. Level B IVIVC was established for each of evaluated solid oral dosage forms, correlation coefficients (r) were 0.97, 0.94 and 0.96 for trimetazidine, indapamide and ciprofloxacin drugs, respectively.</abstract>
<authors>I. E. Shohin, G. V. Ramenskayaand A. Y. Savchenko</authors>
<keywords>In vitro-in vivo correlation (IVIVC), dissolution, trimetazidine, indapamide, ciprofloxacin.</keywords>
<pages>573-580</pages>
</article>
</Journal>
