International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 3 Issue 1
2012 (January - March)
Hepatoprotective Effect Of Daucus Carota Aqueous Root Extract Against Isoniazid And Rifampicin Induced Hepatotoxicity In Rats
The effects of pretreatment and co-administration of aqueous extract of lessThan i greaterThan Daucus carota lessThan /i greaterThan root on anti-tubercular drugs hepatotoxicity in rats were studied. Wistar albino rats were divided into six groups of three rats each. Groups 1 and 2 were normal and test control (administered with anti-tubercular drugs to induce hepatotoxicity) respectively. Groups 3 and 4 were pretreated with 100mg/kg bw and 200mg/kg bw of the extract for 28 days, then administered with anti-tubercular drugs isoniazid (INH) and rifampicin (RMP) at doses of 27mg/kg bw and 54mg/kg bw respectively for same duration. In groups 5 and 6, same doses of the extract and anti-tubercular drugs were administered concurrently for 28 days. Oral administration of the extract lessThan i greaterThan lessThan /i greaterThan significantly (P Ë‚ 0.05) reduced serum ALT, AST, and ALP activities, and uBIL concentrations compared to the test control. The results suggested that aqueous extract of lessThan i greaterThan Daucus carota lessThan /i greaterThan might have had an hepatoprotective effect on anti-tubercular drugs hepatotoxicity in rats
B. Bello And A. M. Wudil
Daucus carota, hepatotoxicity, isoniazid, rifampicin, liver enzymes.
336-342