International Journal of Pharma and Bio Sciences
ijpbs.net
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10.22376/ijpbs.2019.10.1.p1-12
Volume 3 Issue 1
2012 (January - March)
Acute Toxicity Studies Of Fixed Dose Combination Of Ceftriaxone+Sulbactam+Ethylenediaminetetraacetic Acid In Swiss Albino Mice And Sprague Dawley Rats
The acute toxicity study of Ceftriaxone+Sulbactam+Ethylenediaminetetraacetic acid was investigated to offer a solution for the treatment of bacterial infection caused by beta lactam resistant pathogens. A single intra venous injection at the dose levels of 50 mg/Kg, 250 mg/Kg and 500 mg/Kg body weight were administered to lessThan i greaterThan Swiss albino lessThan /i greaterThan mice lessThan i greaterThan lessThan /i greaterThan and lessThan i greaterThan Sprague dawely lessThan /i greaterThan rats (both male and female), where as control groups received normal saline. General behaviour , signs of toxicity, body weight, food and water consumption, and mortality were observed daily for 14 days. At the end of the study , hematological, biochemical, morphological and microscopic parameters were also determined. No toxicological meaningful difference, hazardous symptoms or death were observed in the acute toxicity test which indicates that a single i.v dose of Ceftraixone+sulbactam+EDTA combination at the dose levels of 50 mg/Kg, 250 mg/Kg and 500 mg/Kg body weight was not lethal in both mice and rats (male/female), and suggest a safe use in humans
Manu Chaudhary And Krishnaraju V
Acute toxicity, Mice, Rats,Ceftriaxone +Sulbactam+ EDTA
110-122