10.22376/ijpbs.2019.10.1.p1-12 Volume 1 Issue 4 2010 (October - December) Various direct analogues of flurbriprofen [ 4'-methylbiphenyl-2-(substituted phenyl) carboxamide derivatives ] were synthesized and evaluated for anti-inflammatory activity by carrageenan induced rat paw edema model. Compounds 3g, 3h and 3i were found significantly active. Substituents –SO2NH2, -F and -Cl exhibited significant anti-inflammatory activity. Molecular docking was performed using Glide to study the binding mode of these direct analogues of flurbriprofen. The docking analysis of highest active molecule 3g (Glide XP score -8.39) shows significant interaction with active site amino acid residues. Results of this study indicated that these direct analogues of flurbriprofen have affinity towards COX-2 active site which can further be explored as selective COX-2 inhibitors.  Ujashkumar A. Shah,Nilesh K. Wagh,Hemantkumar S. Deokar,Shivajirao S. Kadam,Vithal M. Kulkarni Biphenyl, Anti-Inflammatory agents, flurbriprofen, Docking 501-511