<?xml version="1.0" encoding="utf-8"?>
<Journal>
<Journal-Info>
<name>International Journal of Pharma and Bio Sciences</name>
<website>ijpbs.net</website>
<email>editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com</email>
</Journal-Info>
<article>
<article-id pub-id-type='other'>10.22376/ijpbs.2019.10.1.p1-12</article-id>
<issue_number>Volume 3 Issue 4</issue_number>
<issue_period>2012(October - December)</issue_period>
<title>COMPARATIVE STUDY OF THREE WILD EDIBLE FRUITS OF UTTRAKHAND FOR ANTIOXIDANT, ANTIPROLIFERATIVE ACTIVITIES AND POLYPHENOLIC COMPOSITION </title>
<abstract> lessThan i greaterThan Ficus palmata, Pyrus pashia lessThan /i greaterThan  and  lessThan i greaterThan Ficus auriculata lessThan /i greaterThan  are the popular wild edible fruits of Uttarakhand. The present study aimed to evaluate their total phenolic, flavonoid contents, antioxidant and antiproliferative activities by using two solvents namely 80% aqueous methanol and acetone lessThan i greaterThan . lessThan /i greaterThan  The results showed highest phenolic and flavonoid contents in the  lessThan i greaterThan Ficus palmata  lessThan /i greaterThan acetone extract lessThan i greaterThan , lessThan /i greaterThan  while lowest in  lessThan i greaterThan Ficus auriculata lessThan /i greaterThan  and  lessThan i greaterThan Pyrus pashia lessThan /i greaterThan  methanol extracts respectively. Antioxidant activities were highest in the acetone extract of Ficus lessThan i greaterThan  palmata lessThan /i greaterThan  and  lessThan i greaterThan Pyrus pashia lessThan /i greaterThan  respectively. RP-HPLC analysis revealed abundance of gallic acid and catechin in all the fruit extracts, while traces of caffeic acid, coumaric acid and ellagic acid. All the fruit extracts possessed antiproliferative activities (22-63%) against cervical cancer cells C33A being highest in  lessThan i greaterThan Ficus palmata, lessThan /i greaterThan  while showing no cytotoxicity to the normal peripheral blood mononuclear cells. Therefore,  lessThan i greaterThan Ficus palmata lessThan /i greaterThan  fruit extracts could be used for the developing herbal formulation that can reduce the oxidative stress and prevent cancer development.</abstract>
<authors>RITU SAINI, VEENA GARG AND KOUSHALYA DANGWAL</authors>
<keywords>Polyphenols, Antioxidant activity, Antiproliferative activity, RP-HPLC.</keywords>
<pages>158-167</pages>
</article>
</Journal>
