10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 4 2012(October - December) The main aim of the present study is to transplant HAE cells as useful cellular replacement to overcome the functional deficits caused by the trimethyltin chloride lesion in the hippocampus. Methods: This study was conducted on the Wistar albino rats. The effect of transplanted human amniotic epithelial cells in hippocampus after trimethyltin chloride lesion was tested on eight-arm radial maze during different time duration. Hippocampal disorder was induced by the intraperitoneal administration of trimethyltin chloride at a single dose of 7.5 mg/kg body weight or two divided doses of 3.75 mg/kg body weight for two days. Human amniotic epithelial cells were isolated from placenta obtained from uncomplicated elective caesarian. Using standard co-ordinates human amniotic epithelial cells were transplanted at four sites of hippocampus. Results: It is observed that the transplanted human amniotic epithelial cells can aid in the partial recovery of performance, tested in eight-arm radial maze after the trimethyltin chloride lesion. Conclusion: The human amniotic epithelial cells may be used as a suitable donor tissue to alleviate various degenerative diseases in animal model before the clinical trials in humans, who are suffering from various degenerative diseases K. V. OMPRAKASH, R. MUTHUSAMY, B. DEVANAND, NAGARAJA PURANIK AND M. MALLIKARJUN Hippocampus, Human amniotic epithelial cells, Radial arm maze, Trimethyltin chloride. 218-224