10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 4 2012(October - December) Out of 280 post parturient crossbred cows between 0 to 60 days post calving presented with the history of reduced feed intake and decreased milk yield, 106 (37.86 %) were found suffering from different subclinical production disorders. On detailed clinical examination and urine analysis, 24 cows (22.64%) were positive for subclinical hypocalcaemia and urine samples were low in calcium levels. Blood samples from study group were analyzed for haemoglobin, haematocrit and certain other parameters. Serum samples were analyzed for calcium, glucose, magnesium, phosphorous, AST, ALP, total protein and albumin and compared with that of control cows. Cows with subclinical hypocalcaemia were randomly divided in to two different groups. Group I (n=12) animals were administered Calup Gel at the rate 300g orally for one day and Rumen-FS bolus at the rate 2 boli orally twice in a day for 5 days. Group II (n=12) animals received Inj. 25% Intacal at the rate 450 ml iv for 3 days and Inj. Tribivet at the rate 10-15 ml im for 3 days. There was a significant improvement in haemoglobin and serum calcium and significant decrease in serum glucose, magnesium and AST levels after the treatment. The comparative means of healthy, group I and II cows revealed that the treatment given to group II was more effective G. AMBICA AND D.S.T. RAO Subclinical hypocalcaemia, Crossbred Cows, Haematological changes, Biochemical changes, Therapy. 225-231