10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 4 2012(October - December) With the intension to screen heavy metal tolerance and antibiotic susceptibility, a bacterium was isolated and characterized from municipal solid waste dumping yard (Dhapa), Kolkata, India. On the basis of biochemical and 16S rDNA sequence profile, it was identified as lessThan i greaterThan Bacillus cereus lessThan /i greaterThan . Tolerance was observed against heavy metals like Cd lessThan sup greaterThan 2+ lessThan /sup greaterThan , Co lessThan sup greaterThan 2+ lessThan /sup greaterThan , Ni lessThan sup greaterThan 2+ lessThan /sup greaterThan , Cr lessThan sup greaterThan 3+ lessThan /sup greaterThan , Pb lessThan sup greaterThan 2+ lessThan /sup greaterThan , Hg lessThan sup greaterThan 2+ lessThan /sup greaterThan by this bacterium and was found that the bacterium was most tolerable to Cd lessThan sup greaterThan 2+ lessThan /sup greaterThan and Cr lessThan sup greaterThan 3+ lessThan /sup greaterThan compared to other four metals. Study of susceptibility of this bacterium was determined by minimum inhibitory concentration (MIC) value of different antibiotics such as chloramphanicol, carbenicillin, tetracycline, erythromycin, ciprofloxacin, norfloxacin and maximum inhibition was observed by chloramphanicol and norfloxacin. A plasmid was isolated from the selected stain with MW of 45 kb. The plasmid curing experiment revealed that this plasmid was very essential for metal resistance power of the selected isolate. MAHAMUDA KHATUN, PARAMITA BERA, DEBMALYA MITRA, ANURUP MANDAL AND AMALESH SAMANTA Bacillus cereus, Heavy Metal, Antibiotic resistance, MIC, Plasmid Curing. 819-829