10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 4 2012(October - December) Suppressor of Cytokine Signaling (SOCS) proteins are the negative regulators of cytokine signals as a natural precaution to prevent excessive responses that could cause damage to body tissues. However, their over expression is suggested to inhibit the anti-proliferative and antiviral activities of Interferon (IFN). Several viruses including HIV-1 have been reported to exploit the SOCS proteins for minimizing the activity of Interferon (IFN). Hence, the attempts to regulate the SOCS expression may be a novel roadblock into viral proliferation and pathogenesis. Present review is an effort to summarize the SOCS contribution in viral contagion and future therapeutic prospects against HIV-1. lessThan i greaterThan Running Head lessThan /i greaterThan - Aberrant SOCS expression: a target for anti-HIV research SARFARAZ ALAM, MANSI SHRIVASTAVA AND LK DWIVEDI HIV-1, Suppressor of Cytokine Signaling (SOCS), Interferon (IFN), JAK/STAT pathway, IL-7 1137-1144