International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 3 Issue 4
2012(October - December)
COMPARATIVE HOMOLOGY MODELING AND DOCKING OF LAMIN A MOLECULE AND ITS INCIDENCE IN PROGERIA
Progeria is a rare and fatal autosomal recessive disorder affecting children, usually newborn babies causing accelerated ageing. It is caused due to mutation in a gene called LMNA which leads to instability of nucleus thereby causing rapid ageing. This means that an individual carrying a mutation in a single gene does not show any sort of symptoms as it is recessive in nature. Moreover 90% of the children have mutation on the gene that encodes protein Lamin A. The gene involved is LMNA which codes this protein and due to one point mutation (mostly) defective fibrous protein is formed leading to unstable nucleus thereby causing premature ageing. Researches are being done as no cure is available till date but some drugs are used in order to subsidies the effects caused. This work deals with establishing a drug or to manipulate analogues of approved drug and to check its effectiveness and binding activity over the receptor protein through docking. For this purpose number of ligands and their analogues were prepared and docked on the receptor lamin A whose structure was obtained through a request from EBI-Swiss model with PDB id as q369. Out of all the drug molecules docked one specific analogue Indinavir showed great results with energy of -94.2 Kcal/mol and good binding capacity, So this drug was manipulated and modified and again docked where better results were obtained with a binding energy of -105.5 Kcal/mol. Using this modified analogue might further aid in the treatment of this disease and can be subjected to clinical validations.
PRIYANKA NARAD, MITALI MALPANI, VAISHALI CHAKRABORTY, AND ABHISHEK SENGUPTA.
Progeria, Lamin A, homology modeling and docking
1164-1170