10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 4 2012(October - December) Plants play an indispensable part in the environment, especially as a medication to protect man from intrinsic and extrinsic ill effects imparted by stress agents. In tune with the search of antioxidant-rich plants, the leaves of lessThan i greaterThan Zea mays lessThan /i greaterThan were analyzed for its antioxidant potential at three different stages of growth. The effect of the leaf extract on the oxidant stress induced in lessThan i greaterThan in vitro lessThan /i greaterThan systems, which simulated lessThan i greaterThan in vivo lessThan /i greaterThan conditions, were studied. The lessThan i greaterThan in vitro lessThan /i greaterThan model used as a means to replace or minimize the use of live animals in experiments was goat liver slices. The aim of the present study was to assess the extent of oxidative stress, the activities and levels of antioxidants by the extracts of lessThan i greaterThan Zea mays lessThan /i greaterThan in the presence and absence of oxidative stress. Our findings suggest that the hepatoprotection by lessThan i greaterThan Zea mays lessThan /i greaterThan leaves against hydrogen peroxide induced oxidative stress could be due to its antioxidant property. KIRUTHIKA BALASUBRAMANIAN AND PALGHAT RAGHUNATHAN PADMA liver slices, oxidative stress, antioxidants, Zea mays leaf extracts. 201-210