10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 4 2012(October - December) Synthesis of a series of new 1, 3, 2- dioxaphosphinane derivatives (3a-j) was accomplished. The key step in the synthesis of 3a-j involves the cyclization reaction of tris (hydroxy methyl) nitromethane (1) with P(X)Cl lessThan sub greaterThan 3 lessThan /sub greaterThan (X=S,O) in presence of TEA in THF at 40-45 °C to afford the phosphoryl mono chloride intermediate (2). The intermediate (2) when treated with different substituted aromatic amines and with a few substituted phenols lessThan i greaterThan in situ lessThan /i greaterThan in the presence of TEA at 0-15 °C afforded 3a-j. The structures of 3a-j were established by IR, NMR (1H, lessThan sup greaterThan 13 lessThan /sup greaterThan C and lessThan sup greaterThan 31 lessThan /sup greaterThan P) and Mass spectral data and elemental analysis. All these compounds exhibited good antimicrobial activity. G. SUBBAREDDY, S.H. JAYA PRAKASH, K. UMA MAHESWARA RAO, E. DADAPEER, B. SATHEESH KRISHNA AND C. SURESH REDDY Aromatic amines, Phenols, Tris(hydroxymethyl)nitromethane, antimicrobial activity, 1,3,2-dioxaphosphinane. 343-352