10.22376/ijpbs.2019.10.1.p1-12 Volume 3 Issue 4 2012(October - December) lessThan i greaterThan Santalum album lessThan /i greaterThan L. is known as East Indian Sandalwood Plant and is well known for its Heartwood. The Sandalwood heartwood contains two major photochemical i.e. lessThan i greaterThan Santalol lessThan /i greaterThan and lessThan i greaterThan Santyl acetate. lessThan /i greaterThan For this study different fractions of Heartwood and leaves are extracting in Soxhlet assembly with organic solvents as well as pure Heartwood oil was extracted by steam distillation method in Clavenger assembly. Fractions and Oil were screened against few human pathogens by disc diffusion method. Methanol fraction and Oil resulted in high potential against lessThan i greaterThan Escherichia lessThan /i greaterThan lessThan i greaterThan coli, lessThan /i greaterThan lessThan i greaterThan Staphylococcus lessThan /i greaterThan lessThan i greaterThan aureus and S.typhi lessThan /i greaterThan . In silico prediction of lessThan i greaterThan Santalol lessThan /i greaterThan and lessThan i greaterThan Santayl acetate lessThan /i greaterThan using PRE-ADMET, shows 100% Human intestinal absorption and plasma protein binding, Positive against carcinogenic cell lines, Positive CNS-Barrier test, which affirms them as potent antibacterial and anticancerus lead compound. KUSHAL K. HIRE and D. A. DHALE Antimicrobial Effect, Heartwood, ADMET, Clavenger and Soxhlet. 727-734